PMID: 11343372May 9, 2001Paper

A GEE approach to estimating sensitivity and specificity and coverage properties of the confidence intervals

Statistics in Medicine
M R Sternberg, A Hadgu

Abstract

A generalized estimating equation (GEE) approach is used to estimate the sensitivity and specificity of five non-culture screening tests for detecting Chlamydia trachomatis in endocervical specimens from women attending family planning clinics. Since the estimates of these parameters can be very close to the upper limit of one, confidence interval construction based on the traditional approaches, such as the delta method or a back-transformation approach, may not have the stated coverage. We compare different approaches to calculating confidence intervals for the sensitivity and specificity from the results of the GEE approach. These methods include the delta method, a back-transformation approach, and a bootstrap approach. In addition, we use simulations to investigate the estimated coverage rates of the delta method and the back-transformation approach. Published in 2001 by John Wiley & Sons, Ltd.

References

Aug 1, 1992·Statistics in Medicine·P J Smith, A Hadgu
Jun 15, 1997·Statistics in Medicine·W LeisenringG Longton
Jan 1, 1999·Statistical Methods in Medical Research·S L Hui, X H Zhou
Feb 13, 1999·Journal of Clinical Microbiology·W J NewhallW E Stamm

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Citations

Oct 7, 2005·Journal of Clinical Microbiology·Khalil G GhanemLauri E Markowitz
Aug 22, 2009·Biometrical Journal. Biometrische Zeitschrift·Alexander R de LeonChristopher J Rudnisky
Apr 23, 2010·Tropical Medicine & International Health : TM & IH·L SanchezP Van der Stuyft
Jun 5, 2014·BioMed Research International·U AyalaD González-Otero
Jan 27, 2015·Resuscitation·U AyalaT Eftestøl
Oct 30, 2014·International Urogynecology Journal·Peggy A NortonL Cannon-Albright
Feb 20, 2020·Circulation Journal : Official Journal of the Japanese Circulation Society·Yuki TanabeTeruhito Mochizuki
Dec 3, 2010·Clinical Pharmacology and Therapeutics·M H HaniganD M Thompson
Sep 7, 2019·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Esther M JohnDee W West
Jun 27, 2021·Journal of Digital Imaging·Robert D E HendersonPaul Babyn
Jul 2, 2021·Cancer Imaging : the Official Publication of the International Cancer Imaging Society·Kartik S JhaveriSteven Gallinger

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