A gelatin based antioxidant enriched biomaterial by grafting and saturation: towards sustained drug delivery from antioxidant matrix

Colloids and Surfaces. B, Biointerfaces
I Selestin Raja, Nishter Nishad Fathima

Abstract

Proteins grafted with antioxidant molecules have drawn much attention due to their increased life time and biocompatibility. When protein macromolecules are cross linked chemically and physically with antioxidant molecules, they can act as antioxidant biomaterials as well as scaffolds to release the antioxidant molecules by diffusion. In our work, we have attempted to release catechin molecules from the matrix of glutathione grafted gelatin. Conjugation of glutathione and cross linkage was done by carbodiimide method to achieve smaller pores in the gelatin matrix and the characterization was performed by means of FTIR-ATR and calorimetric analyses. The glutathione grafted gelatin (GGSH) has been shown to have more thermal stability and pores with lesser radii than blank gelatin (bGEL). Free radical scavenging activity of GGSH was also found to be more than that of bGEL. Catechin was added to GGSH and bGEL by physical blending in order to achieve short term release of antioxidant molecules. CD spectra revealed that significant conformational changes occurred in secondary structure of gelatin upon interaction with catechin. Slower rate of catechin release from GGSH reflected the influence of cross linkage and physical interactive...Continue Reading

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Oct 16, 2013·Colloids and Surfaces. B, Biointerfaces·Jina Susan VargheseNishter Nishad Fathima
Jan 23, 2014·ACS Applied Materials & Interfaces·Kunal MondalAshutosh Sharma

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Citations

Jun 2, 2016·Advanced Materials·Hoda NassiraRaffaele Mezzenga
Dec 20, 2016·Analytical Chemistry·Sagarika BhattacharyaRaz Jelinek
Jul 18, 2019·Nanomaterials·Iruthayapandi Selestin RajaDong-Wook Han
Jun 20, 2020·Drug Delivery and Translational Research·Diego R C PascoalSilvio A B Vieira de Melo

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