A GEMPix-based integrated system for measurements of 3D dose distributions in water for carbon ion scanning beam radiotherapy

Medical Physics
Johannes LeidnerMarco Silari

Abstract

Commercially available systems for ion beam reference dosimetry in water are mainly based on ionization chambers. In those systems, a large number of small detectors are typically arranged in a two-dimensional (2D) array or matrix to achieve high spatial resolution (order of several millimeters) and large field coverage at the same time. The goal of this work was to investigate the reliability of a detector of superior spatial resolution to perform three-dimensional (3D) ionization measurements in carbon ion pencil beams. The GEMPix is a small gaseous detector with a highly pixelated readout, consisting of a drift region (with 2.8 cm3  × 2.8 cm3  × 0.3 cm3 volume), three gas electron multipliers (GEMs) for signal amplification and four Timepix ASICs with 55 µm pixel pitch and a total of 262,144 pixels. An integrated system was designed and built, which consists of a commercial water phantom with a three-axis motorized arm, a reference large-area ionization chamber for signal normalization to the beam output and the GEMPix itself. Measurements at different depths in water have been performed at the Italian National Centre for Oncological Hadrontherapy (CNAO) with three carbon ion beam energies. Lateral beam profiles measured wit...Continue Reading

References

Aug 13, 2008·Physics in Medicine and Biology·E SeravalliB Voss
May 30, 2009·Physics in Medicine and Biology·E SeravalliC W E van Eijk
Apr 5, 2015·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Sandro Rossi
Mar 19, 2016·Physics in Medicine and Biology·D NichiporovA V Klyachko
Dec 3, 2017·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·S GiordanengoA Vignati

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Software Mentioned

PTW Peakfinder
Timepix
CNAO
LabVIEW
GEMPix
FLUKA
Pixelman

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