A gender-specific association between the serotonin transporter gene and suicide attempts

Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology
Enrique Baca-GarcíaJose de Leon

Abstract

This pilot study tested the gender-specificity of the association between suicide attempts and a polymorphism in the promoter area of the serotonin transporter with two allelic variants, a long (1) variant and a short (s) variant. In a Spanish general hospital, 180 suicide attempters (121 women and 59 men) and 212 control blood donors (93 women and 119 men) were recruited. Subjects were classified as S individuals (s/s or s/l) with low expression of the serotonin transporter, and L individuals (l/l) with high expression. S individuals were significantly overrepresented (or L, underrepresented) in female attempters when compared with female controls and male attempters. Lethality appeared to have a significant influence on the effects of the genotype in suicide since S females were overrepresented among non-lethal female attempters. Further studies are needed to replicate that the serotonin genotype polymorphism may influence suicide attempts only in females.

Citations

Jan 31, 2004·Progress in Neuro-psychopharmacology & Biological Psychiatry·Enrique Baca-GarciaJose de Leon
May 24, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Enrique Baca-GarcíaJose de Leon
Dec 9, 2003·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Nikolaus ThierrySiegfried Kasper
Dec 17, 2009·Molecular Psychiatry·L M FioriG Turecki
Jul 26, 2008·Epidemiologic Reviews·Matthew K NockSing Lee
Jul 21, 2009·Primary Care Companion to the Journal of Clinical Psychiatry·Nicole S LuddingtonRif S El-Mallakh
Mar 15, 2008·Archives of Suicide Research : Official Journal of the International Academy for Suicide Research·Juan J CarballoMaria A Oquendo
Sep 26, 2013·Indian Journal of Pediatrics·Paul Swamidhas Sudhakar RussellBeulah Samuel
May 24, 2012·Journal of Psychiatric Practice·Benjamin J Sadock
May 24, 2011·Biological Psychology·Sarah WhittleNicholas B Allen
Nov 1, 2015·Journal of Affective Disorders·F GressierA Serretti
Sep 6, 2006·Child and Adolescent Psychiatric Clinics of North America·Gil ZalsmanJ John Mann
Mar 22, 2016·International Journal of Molecular Sciences·Sang Won Jeon, Yong-Ku Kim
Apr 12, 2005·Schizophrenia Research·Enrique Baca-GarciaJose de Leon
Aug 30, 2005·Biological Psychiatry·Catalina Lopez de LaraGustavo Turecki
Apr 29, 2008·The Psychiatric Clinics of North America·Jelena BrezoGustavo Turecki
May 20, 2009·Psychiatric Genetics·Florence GressierEmmanuelle Corruble
Feb 8, 2006·Molecular Psychiatry·B BondyP Zill
Mar 26, 2003·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·David C Purselle, Charles B Nemeroff
Sep 16, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Luis Jiménez-TreviñoJulio Bobes

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