PMID: 9449708Mar 21, 1998Paper

A gene encoding antigenic peptides of human squamous cell carcinoma recognized by cytotoxic T lymphocytes

The Journal of Experimental Medicine
S ShichijoK Itoh

Abstract

Except for melanomas, tumor antigens recognized by cytotoxic T lymphocytes (CTLs) are yet unidentified. We have identified a gene encoding antigenic peptides of human squamous cell carcinomas (SCCs) recognized by human histocompatibility leukocyte antigens (HLA)- A2601-restricted CTLs. This gene showed no similarity to known sequences, and encoded two (125- and 43-kilodalton [kD]) proteins. The 125-kD protein with the leucine zipper motif was expressed in the nucleus of the majority of proliferating cells tested, including normal and malignant cells. The 43-kD protein was expressed in the cytosol of most SCCs from various organs and half of lung adenocarcinomas, but was not expressed in other cancers nor in a panel of normal tissues. The three nonapeptides shared by the two proteins were recognized by the KE4 CTLs, and one of the peptides induced in vitro from peripheral blood mononuclear cells (PBMCs) the CTLs restricted to the autologous tumor cells. The 43-kD protein and this nonapeptide (KGSGKMKTE) may be useful for the specific immunotherapy of HLA-A2601(+) epithelial cancer patients.

References

Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A NomotoE Wimmer
Feb 1, 1989·The Journal of Cell Biology·M Kozak
Nov 4, 1988·Cell·T Curran, B R Franza
Jun 22, 1995·International Journal of Cancer. Journal International Du Cancer·S ShichijoK Itoh
May 1, 1995·Tissue Antigens·M MutoC Asagami
Oct 1, 1994·AIDS·K H Choi, T J Coates
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y KawakamiS A Rosenberg
Apr 26, 1994·Proceedings of the National Academy of Sciences of the United States of America·Y KawakamiS A Rosenberg
Sep 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·V OssipowU Schibler
Sep 1, 1995·Tissue Antigens·K L Arnett, P Parham
Mar 1, 1996·The Journal of Experimental Medicine·R F WangS A Rosenberg
Mar 1, 1996·The Journal of Experimental Medicine·P F RobbinsS A Rosenberg
Nov 1, 1995·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·B LarsenR F Gesteland
Dec 11, 1995·International Journal of Cancer. Journal International Du Cancer·M MarchandY Humblet
Dec 1, 1996·The Journal of Experimental Medicine·R F WangS A Rosenberg
Aug 29, 1997·The Journal of Experimental Medicine·S MandruzzatoP van der Bruggen

❮ Previous
Next ❯

Citations

Feb 6, 1999·International Journal of Cancer. Journal International Du Cancer·M KawamotoK Itoh
Apr 21, 1999·International Journal of Cancer. Journal International Du Cancer·M KikuchiK Itoh
Dec 22, 1999·International Journal of Cancer. Journal International Du Cancer·T ImaizumiK Itoh
Dec 5, 2000·International Journal of Cancer. Journal International Du Cancer·T IwasakiM Okada
Feb 22, 2002·International Journal of Cancer. Journal International Du Cancer·Nobuaki SuzukiKyogo Itoh
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·K HaradaS Shichijo
Mar 10, 2001·Biochemical and Biophysical Research Communications·T NakatsuraY Nishimura
Jan 13, 2001·Diseases of the Colon and Rectum·T SasatomiK Shirouzu
Nov 25, 2000·Breast Cancer : the Journal of the Japanese Breast Cancer Society·Y ObataS Miura
Mar 11, 2011·Cellular and Molecular Life Sciences : CMLS·Shelley R Starck, Nilabh Shastri
Apr 20, 2004·Cancer Immunology, Immunotherapy : CII·Thomas K HoffmannTheresa L Whiteside
Aug 17, 2004·Cancer Immunology, Immunotherapy : CII·Luisa NovellinoGiorgio Parmiani
Feb 3, 2012·Cellular and Molecular Neurobiology·Neetu SinghVikas Mishra
Apr 9, 2008·Journal of Biomedical Science·Annie A WuSara I Pai
Dec 21, 2000·Current Oncology Reports·T L Whiteside
Jun 12, 2001·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·N TsudaA Yamada
Jun 4, 2011·Leukemia·S K MartinA C W Zannettino
Jan 20, 1999·The Journal of Experimental Medicine·H DolstraE van de Wiel-van Kemenade
Feb 28, 2002·Annual Review of Immunology·Nilabh ShastriThomas Serwold
Apr 27, 2000·American Journal of Respiratory Cell and Molecular Biology·S M DubinettS Sharma
Apr 8, 2009·Critical Reviews in Immunology·Hideho OkadaMitsugu Fujita
Jul 2, 2011·High Altitude Medicine & Biology·Martha C Tissot van Patot, Max Gassmann
Nov 4, 2000·Expert Opinion on Investigational Drugs·L A Jones, M L Salgaller
Mar 21, 2002·Cancer Investigation·Alexei F KirkinJesper Zeuthen
Feb 24, 2009·Trends in Immunology·Rudolf ValentaHarald Renz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.