A gene for recessive nonsyndromic sensorineural deafness (DFNB18) maps to the chromosomal region 11p14-p15.1 containing the Usher syndrome type 1C gene

Genomics
P K JainE R Wilcox

Abstract

Autosomal recessive nonsyndromic sensorineural deafness segregating in a large consanguineous Indian family was mapped to chromosome 11p14-p15.1 defining a new locus, DFNB18. A maximum lod score of 4.4 at theta = 0 was obtained for the polymorphic micro-satellite marker D11S1888. Haplotype analysis localizes this gene between markers D11S1307 and D11S2368, which is approximately 1.6 cM and encompasses the region of Usher syndrome type 1C (USH1C). We postulate that DFNB18 and USH1C are allelic variants of the same gene.

References

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Citations

May 20, 1999·Clinical Genetics·N G Robertson, C C Morton
Nov 10, 2001·Annual Review of Genomics and Human Genetics·C Petit
Jun 2, 2012·Frontiers in Bioscience (Landmark Edition)·Duygu Duman, Mustafa Tekin
Jun 6, 2003·Clinical Genetics·Z M AhmedE R Wilcox
Apr 19, 2003·Clinical Genetics·D C BlaydonM Bitner-Glindzicz
May 3, 2006·Clinical Genetics·M B Petersen, P J Willems
Nov 9, 2001·Annual Review of Genetics·C PetitJ P Hardelin
Mar 7, 2000·American Journal of Medical Genetics·R A SundstromR J Smith
Feb 2, 2000·Nature Genetics·M C SimmlerJ J Panthier
Jan 3, 2019·Genomics & Informatics·Nathanial T Carpena, Min Young Lee
Jul 1, 2004·Indian Journal of Pediatrics·Manju GhoshMadhulika Kabra
Jul 3, 2021·International Journal of Molecular Sciences·Carla Fuster-GarcíaGema García-García

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