A gene interaction network‑based method to measure the common and heterogeneous mechanisms of gynecological cancer

Molecular Medicine Reports
Mingyuan WangJinjin Wang

Abstract

Gynecological malignancies are a leading cause of mortality in the female population. The present study intended to identify the association between three severe types of gynecological cancer, specifically ovarian cancer, cervical cancer and endometrial cancer, and to identify the connective driver genes, microRNAs (miRNAs) and biological processes associated with these types of gynecological cancer. In the present study, individual driver genes for each type of cancer were identified using integrated analysis of multiple microarray data. Gene Ontology (GO) has been used widely in functional annotation and enrichment analysis. In the present study, GO enrichment analysis revealed a number of common biological processes involved in gynecological cancer, including 'cell cycle' and 'regulation of macromolecule metabolism'. Kyoto Encyclopedia of Genes and Genomes pathway analysis is a resource for understanding the high‑level functions and utilities of a biological system from molecular‑level information. In the present study, the most common pathway was 'cell cycle'. A protein‑protein interaction network was constructed to identify a hub of connective genes, including minichromosome maintenance complex component 2 (MCM2), matrix m...Continue Reading

References

Jan 1, 1991·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·V J Uitto, H Larjava
May 28, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Z DeylA Eckhardt
Jul 8, 2003·The Journal of Pathology·Fred T Bosman, Ivan Stamenkovic
Apr 18, 2007·Genes & Development·Yong Sun Lee, Anindya Dutta
Dec 7, 2007·Proceedings of the National Academy of Sciences of the United States of America·Shuangli MiJianjun Chen
Sep 6, 2008·Nature·UNKNOWN Cancer Genome Atlas Research Network
Oct 18, 2008·Nucleic Acids Research·Qinghua JiangYunlong Liu
Nov 8, 2008·Nucleic Acids Research·T S Keshava PrasadAkhilesh Pandey
Mar 24, 2009·EMBO Reports·Anaïs BaudotAlfonso Valencia
Oct 29, 2009·Carcinogenesis·Pamela K Kreeger, Douglas A Lauffenburger
Apr 10, 2010·Nature Biotechnology·Margus LukkAlvis Brazma
Nov 26, 2010·Nucleic Acids Research·Tanya BarrettAlexandra Soboleva
Apr 15, 2011·BMC Medical Genomics·Christopher A MillerAleksandar Milosavljevic
Jun 10, 2011·Genome Research·Fabio VandinBenjamin J Raphael
Jul 2, 2011·Nature·UNKNOWN Cancer Genome Atlas Research Network
Jul 15, 2011·Bioinformatics·Catherine Stamoulis, Rebecca A Betensky
Sep 13, 2011·Genome Research·Giovanni CirielloNikolaus Schultz
May 23, 2012·Cell·Serena Nik-ZainalUNKNOWN Breast Cancer Working Group of the International Cancer Genome Consortium
Jun 5, 2013·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Veronica Wendy SetiawanPamela L Horn-Ross
Feb 25, 2014·The Journal of Surgical Research·Curtis J WrayFilemon K Tan
Mar 20, 2014·Seminars in Cell & Developmental Biology·S Champeris TsanirasS Taraviras
Sep 23, 2014·BioMed Research International·Nicholas E Simon, Anthony Schwacha
Nov 25, 2014·Nucleic Acids Research·Ioannis S VlachosArtemis G Hatzigeorgiou
Dec 3, 2015·Nucleic Acids Research·Yoav D ShaulDavid M Sabatini
Jun 9, 2016·International Journal of Molecular Sciences·Pavida PittayapruekMamitaro Ohtsuki

❮ Previous
Next ❯

Software Mentioned

DAVID
Database for Annotation , Visualization and Integrated Discove...
R
Cytoscape
Linear Models for Microarray Data
MERAV

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.