A gene regulatory network for apical organ neurogenesis and its spatial control in sea star embryos.

BioRxiv : the Preprint Server for Biology
Alys JarvelaVeronica F Hinman

Abstract

How neural stem cells generate the correct number and type of differentiated neurons in appropriate places is an important question in developmental biology. Although nervous systems are diverse across phyla, many taxa have a larva that forms an anterior concentration of neurons, or apical organ. The number of neurons in these organs is highly variable. We show that neurogenesis in the sea star larvae begins with soxc-expressing multipotent progenitors. These give rise to restricted progenitors that express lhx2/9. Soxc- and lhx2/9-expressing cells are capable of undergoing both asymmetric divisions, which allow for progression towards a particular neural fate, and symmetric proliferative divisions. Nested concentric domains of gene expression along the anterior-posterior (AP) axis, which have been observed in a great diversity of metazoans, control neurogenesis in the sea star by promoting particular division modes and progression towards becoming a neuron. This work, therefore, explains how spatial patterning in the ectoderm controls progression of neurogenesis. Modification to the sizes of these AP territories provides a simple mechanism to explain the diversity of neuron number found among apical organs.

Related Concepts

Cell Division
Gene Expression
Larva
Neurons
Spatial Distribution
Starfish
Stem Cells
Organ
Disease Progression
Place

Related Feeds

BioRxiv & MedRxiv Preprints

BioRxiv and MedRxiv are the preprint servers for biology and health sciences respectively, operated by Cold Spring Harbor Laboratory. Here are the latest preprint articles (which are not peer-reviewed) from BioRxiv and MedRxiv.

Adult Stem Cells

Adult stem cells reside in unique niches that provide vital cues for their survival, self-renewal, and differentiation. They hold great promise for use in tissue repair and regeneration as a novel therapeutic strategies. Here is the latest research.

Related Papers

Current Opinion in Neurobiology
Delphine DelaunayFumio Matsuzaki
Nature Reviews. Molecular Cell Biology
Magdalena Götz, Wieland B Huttner
Proceedings of the National Academy of Sciences of the United States of America
Kristen A YankuraVeronica F Hinman
Current Opinion in Neurobiology
Weimin Zhong, William Chia
© 2021 Meta ULC. All rights reserved