A gene that encodes a protein consisting solely of zinc finger domains is preferentially expressed in transformed mouse cells.

Molecular and Cellular Biology
M Ernoult-LangeD Hamer

Abstract

We describe the cloning and characterization of the mouse MOK-2 gene, a new member of the Krüppel family of zinc finger proteins. Sequencing of both cDNA and genomic clones showed that the predicted MOK-2 protein consists of seven zinc finger domains with only five additional amino acids. The finger domains of MOK-2 are highly homologous to one another but not to those of other zinc finger proteins. MOK-2 is preferentially expressed in transformed cell lines, brain tissue, and testis tissue. Its possible role in cellular transformation is discussed.

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Citations

Oct 16, 1999·DNA Sequence : the Journal of DNA Sequencing and Mapping·D PetroniP Comi
Jun 6, 2009·The FEBS Journal·Maryannick HarperMichèle Ernoult-Lange
Dec 7, 2013·Biochemical and Biophysical Research Communications·Anand Ramanathan, Nancy Karuri
Jan 1, 1991·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A Ashworth, P Denny
Jan 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·V ArranzM Ernoult-Lange
Jan 1, 1994·Journal of Bacteriology·L A Sayavedra-SotoD J Arp

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