Jul 1, 2016

A Genealogical Look at Shared Ancestry on the X Chromosome

Genetics
Vince BuffaloGraham Coop

Abstract

Close relatives can share large segments of their genome identical by descent (IBD) that can be identified in genome-wide polymorphism data sets. There are a range of methods to use these IBD segments to identify relatives and estimate their relationship. These methods have focused on sharing on the autosomes, as they provide a rich source of information about genealogical relationships. We hope to learn additional information about recent ancestry through shared IBD segments on the X chromosome, but currently lack the theoretical framework to use this information fully. Here, we fill this gap by developing probability distributions for the number and length of X chromosome segments shared IBD between an individual and an ancestor k generations back, as well as between half- and full-cousin relationships. Due to the inheritance pattern of the X and the fact that X homologous recombination occurs only in females (outside of the pseudoautosomal regions), the number of females along a genealogical lineage is a key quantity for understanding the number and length of the IBD segments shared among relatives. When inferring relationships among individuals, the number of female ancestors along a genealogical lineage will often be unkno...Continue Reading

  • References37
  • Citations1

References

  • References37
  • Citations1

Citations

Mentioned in this Paper

Gene Polymorphism
Genome-Wide Association Study
Patterns
Genome
Chromosomes, Human, X
Genetics, Population
Recombination, Genetic
Genetic Pedigree
Heraldry
Homologous Recombination

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