A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes

Chemical Communications : Chem Comm
Cristina ChamorroRob M J Liskamp

Abstract

In this Communication, the access to three different peptide loops attached to a small triazacyclophane (TAC) scaffold molecule for the mimicry of discontinuous epitopes present in, for example, antibodies is described for the first time.

References

Aug 8, 2006·Chembiochem : a European Journal of Chemical Biology·Yashveer SinghPascal Dumy
Jan 11, 2007·Angewandte Chemie·Raimo FrankeJutta Eichler
Sep 22, 2007·Chembiochem : a European Journal of Chemical Biology·Dirk-Jan van ZoelenRob M J Liskamp
Mar 26, 2008·Chemical Communications : Chem Comm·H Bauke AlbadaRob M J Liskamp

Citations

Jan 17, 2012·Journal of Medicinal Chemistry·Christopher J ArnuschYechiel Shai
May 23, 2014·Organic & Biomolecular Chemistry·Helmus van de LangemheenRob M J Liskamp
Mar 8, 2013·Organic & Biomolecular Chemistry·Gwenn E MulderRob M J Liskamp
Sep 1, 2012·Chemical Communications : Chem Comm·Gwenn E MulderRob M J Liskamp
Feb 3, 2016·Frontiers in Bioengineering and Biotechnology·Andrea GroßJutta Eichler
Nov 22, 2011·Organic & Biomolecular Chemistry·David M BealLyn H Jones
Oct 20, 2012·The Journal of Organic Chemistry·Helmus van de LangemheenRob M J Liskamp
Jul 31, 2012·Journal of the American Chemical Society·Partha S Ghosh, Andrew D Hamilton
Apr 9, 2014·Organic Letters·Helmus van de LangemheenRob M J Liskamp
Oct 30, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Benjamin FabreJiří Jiráček

Related Concepts

Triazacyclophane
Antigenic Specificity
Aza Compounds
Heterocyclic Compounds, 2-Ring
Cyclic Peptides
Protein Conformation
Mass Spectrometry
Biomimetics
Epitopes
Peptides

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