A general approach for the non-stop solid phase synthesis of TAC-scaffolded loops towards protein mimics containing discontinuous epitopes

Chemical Communications : Chem Comm
Cristina ChamorroRob M J Liskamp


In this Communication, the access to three different peptide loops attached to a small triazacyclophane (TAC) scaffold molecule for the mimicry of discontinuous epitopes present in, for example, antibodies is described for the first time.


Aug 8, 2006·Chembiochem : a European Journal of Chemical Biology·Yashveer SinghPascal Dumy
Jan 11, 2007·Angewandte Chemie·Raimo FrankeJutta Eichler
Sep 22, 2007·Chembiochem : a European Journal of Chemical Biology·Dirk-Jan van ZoelenRob M J Liskamp
Mar 26, 2008·Chemical Communications : Chem Comm·H Bauke AlbadaRob M J Liskamp


Jan 17, 2012·Journal of Medicinal Chemistry·Christopher J ArnuschYechiel Shai
May 23, 2014·Organic & Biomolecular Chemistry·Helmus van de LangemheenRob M J Liskamp
Mar 8, 2013·Organic & Biomolecular Chemistry·Gwenn E MulderRob M J Liskamp
Sep 1, 2012·Chemical Communications : Chem Comm·Gwenn E MulderRob M J Liskamp
Feb 3, 2016·Frontiers in Bioengineering and Biotechnology·Andrea GroßJutta Eichler
Nov 22, 2011·Organic & Biomolecular Chemistry·David M BealLyn H Jones
Oct 20, 2012·The Journal of Organic Chemistry·Helmus van de LangemheenRob M J Liskamp
Jul 31, 2012·Journal of the American Chemical Society·Partha S Ghosh, Andrew D Hamilton
Apr 9, 2014·Organic Letters·Helmus van de LangemheenRob M J Liskamp
Oct 30, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Benjamin FabreJiří Jiráček

Related Concepts

Antigenic Specificity
Aza Compounds
Heterocyclic Compounds, 2-Ring
Cyclic Peptides
Protein Conformation
Mass Spectrometry

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.