A general diastereoselective synthesis of highly functionalized ferrocenyl ambiphiles enabled on a large scale by electrochemical purification

Chemical Communications : Chem Comm
Emmanuel LerayerJean-Cyrille Hierso

Abstract

A general synthesis of highly functionalized ferrocenes, which include (P,B)- and (N,B)-ambiphiles, has been developed at a multigram scale. Diastereoselective stepwise modification of di-tert-butylated ferrocenes included the unprecedented separation of electroactive species. Bulky alkyl groups on ferrocenes ensure planar chirality of ambiphiles and enforce closer proximity of antagonist Lewis functions.

References

Mar 10, 2001·Angewandte Chemie·Pierre Braunstein, Frédéric Naud
Jul 24, 2004·Chemical Society Reviews·Robert C J AtkinsonNicholas J Long
Dec 8, 2004·Chemistry : a European Journal·Matthias ScheibitzMatthias Wagner
Feb 14, 2006·Angewandte Chemie·Sébastien BontempsDidier Bourissou
Sep 14, 2006·Journal of the American Chemical Society·Sébastien BontempsDidier Bourissou
Nov 18, 2006·Science·Gregory C WelchDouglas W Stephan
Jan 30, 2008·Angewandte Chemie·Holger BraunschweigThomas Kupfer
Dec 17, 2008·Dalton Transactions : an International Journal of Inorganic Chemistry·Istemi KuzuFrank Breher
Dec 22, 2009·Chemical Communications : Chem Comm·Ian R MorganSimon Aldridge
Dec 22, 2009·Angewandte Chemie·Douglas W Stephan, Gerhard Erker
Mar 20, 2010·Chemical Reviews·Holger BraunschweigAchim Schneider
Nov 26, 2010·Chemical Communications : Chem Comm·Abderrahmane Amgoune, Didier Bourissou
Dec 1, 2010·Dalton Transactions : an International Journal of Inorganic Chemistry·Holger Braunschweig, Rian D Dewhurst
Dec 8, 2010·Chemical Communications : Chem Comm·Charles H DevillersDominique Lucas
Sep 8, 2011·Chemical Communications : Chem Comm·Josée BoudreauFrédéric-Georges Fontaine
Dec 13, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Michael S InkpenNicholas J Long
Jun 6, 2013·Chemistry, an Asian Journal·Hajime Kameo, Hiroshi Nakazawa
Jun 12, 2013·Journal of the American Chemical Society·Marc-André CourtemancheFrédéric-Georges Fontaine
Jan 29, 2014·Journal of the American Chemical Society·Xiaowu WangGerhard Erker
May 23, 2015·Chemical Communications : Chem Comm·Marc-André CourtemancheFrédéric-Georges Fontaine
Jun 23, 2015·Inorganic Chemistry·Alex R PetrovUlrich Siemeling
Aug 1, 2015·Science·Marc-André LégaréFrédéric-Georges Fontaine
Nov 17, 2015·Chemical Society Reviews·Ghenwa Bouhadir, Didier Bourissou
Mar 24, 2016·Chemical Communications : Chem Comm·Marc-André LégaréFrédéric-Georges Fontaine
May 18, 2016·Chemical Communications : Chem Comm·Anis TliliThibault Cantat
Oct 11, 2016·Chemical Communications : Chem Comm·Danny SchuhknechtMichael E Tauchert

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Citations

Apr 11, 2018·Angewandte Chemie·Alain C Tagne KuateFrieder Jäkle
Jul 13, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Emmanuel LerayerJean-Cyrille Hierso

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