A general framework for comparative Bayesian meta-analysis of diagnostic studies

BMC Medical Research Methodology
Joris Menten, Emmanuel Lesaffre

Abstract

Selecting the most effective diagnostic method is essential for patient management and public health interventions. This requires evidence of the relative performance of alternative tests or diagnostic algorithms. Consequently, there is a need for diagnostic test accuracy meta-analyses allowing the comparison of the accuracy of two or more competing tests. The meta-analyses are however complicated by the paucity of studies that directly compare the performance of diagnostic tests. A second complication is that the diagnostic accuracy of the tests is usually determined through the comparison of the index test results with those of a reference standard. These reference standards are presumed to be perfect, i.e. allowing the classification of diseased and non-diseased subjects without error. In practice, this assumption is however rarely valid and most reference standards show false positive or false negative results. When an imperfect reference standard is used, the estimated accuracy of the tests of interest may be biased, as well as the comparisons between these tests. We propose a model that allows for the comparison of the accuracy of two diagnostic tests using direct (head-to-head) comparisons as well as indirect comparisons...Continue Reading

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Citations

Sep 23, 2016·Statistical Methods in Medical Research·Victoria N NyagaMarc Arbyn
May 9, 2019·PLoS Neglected Tropical Diseases·Paul AroraJason R Andrews
Feb 23, 2020·Orthopaedic Journal of Sports Medicine·Fanxiao LiuFei Xiong
Jul 10, 2018·Statistical Methods in Medical Research·Victoria N NyagaMarc Aerts
May 31, 2018·BMC Pediatrics·Reem Al KhalifahLehana Thabane
May 17, 2019·Diagnostic and Prognostic Research·Mariska M G Leeflang, Johannes B Reitsma
Dec 2, 2017·Statistics in Medicine·Annika Hoyer, Oliver Kuss
Sep 20, 2020·Journal of the American Medical Directors Association·Ming-Yen HsiaoDer-Sheng Han
Sep 1, 2021·Journal of Evidence-based Medicine·Jinhui TianFujian Song
Sep 24, 2021·The Cochrane Database of Systematic Reviews·Isabelle Ma van GrutingAbdul H Sultan

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