A General Overview on Non-coding RNA-Based Diagnostic and Therapeutic Approaches for Liver Diseases

Frontiers in Pharmacology
Sanchari RoyChristoph Roderburg

Abstract

Liver diseases contribute to the global mortality and morbidity and still represent a major health problem leading to the death of people worldwide. Although there are several treatment options available for Hepatitis C infections, for most liver disease the pharmacological options are still limited. Therefore, the development of new targets against liver diseases is of high interest. Non-coding RNA (ncRNA) such as microRNA (miRNA) or long ncRNA (lncRNA) have been shown to be deeply involved in the pathophysiology of almost all acute and chronic liver diseases. The emerging evidence showed the potential therapeutic use of miRNA associated with different steps of hepatic pathophysiology. In the present review, we summarize emerging insights of ncRNA in liver diseases. We also highlight example of ncRNAs participating in the pathogenesis of different forms of liver disease and how they can be used as potential therapeutic targets for novel treatment paradigms. Furthermore, we describe an overview of up-to-date clinical trials and discuss about its future in clinical applications. Finally, we highlight the role of circulating ncRNAs in diagnosis of liver diseases and discuss the challenges and drawbacks of the usage of ncRNAs in c...Continue Reading

References

Nov 1, 2005·Nature·Jan KrützfeldtMarkus Stoffel
Feb 7, 2006·Cell Metabolism·Christine EsauBrett P Monia
Mar 3, 2006·Genes & Development·Marco Antonio Valencia-SanchezRoy Parker
Aug 19, 2007·Nature Methods·Margaret S EbertPhillip A Sharp
Feb 23, 2008·Journal of Hepatology·Muriel GirardAlexandra Henrion-Caude
Aug 19, 2008·Journal of Hepatology·Henrik Petrowsky, Ronald W Busuttil
Jan 8, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Nicholas J HandJoshua R Friedman
Jun 6, 2009·Expert Review of Anticancer Therapy·Lorenza Rimassa, Armando Santoro
Aug 13, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laura GramantieriMassimo Negrini
Sep 4, 2009·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Enpeng ZhaoAlan D Attie
Oct 5, 2010·Nature Reviews. Drug Discovery·Ramiro GarzonCarlo M Croce
Oct 5, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Christoph RoderburgTom Luedde
Mar 3, 2011·The Journal of Clinical Investigation·Mirco CastoldiMartina U Muckenthaler
Apr 27, 2011·The Journal of Experimental Medicine·Taewan KimCarlo M Croce
May 10, 2011·Annual Review of Nutrition·Kathryn J MooreCarlos Fernández-Hernando
Jun 10, 2011·Nucleic Acids Research·Daniel W ThomsonGregory J Goodall
Jun 10, 2011·Nature·Mirko TrajkovskiMarkus Stoffel
Jun 18, 2011·Biochimica Et Biophysica Acta·Ying Poi Liu, Ben Berkhout
Jul 8, 2011·World Journal of Gastroenterology : WJG·Gunter MaubachLang Zhuo
Jul 15, 2011·Gene Therapy·K A Lennox, M A Behlke
Aug 2, 2011·Cell Metabolism·Anders M Näär
Nov 23, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Jian ZhouJia Fan
Jan 14, 2012·Expert Opinion on Therapeutic Targets·Alexander H Stegh
Jan 27, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Ashley M LaknerLaura W Schrum
Jan 31, 2012·Chemistry & Biology·John C Burnett, John J Rossi
Mar 23, 2012·Nature Reviews. Molecular Cell Biology·Veerle Rottiers, Anders M Näär
Aug 24, 2012·Genes·Mihaela Pertea
Oct 30, 2012·Molecular Oncology·Martin D Jansson, Anders H Lund
Jan 18, 2013·Arteriosclerosis, Thrombosis, and Vascular Biology·Carlos Fernández-HernandoYajaira Suárez
Mar 19, 2013·Trends in Immunology·Mario Leonardo SquadritoMikael J Pittet
Mar 29, 2013·The New England Journal of Medicine·Harry L A JanssenMichael R Hodges
May 7, 2013·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jun WeiXiaoming Fan
Jun 19, 2013·Journal of Hepatology·Alfica SehgalKevin Fitzgerald

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Citations

Jun 10, 2019·Environmental and Molecular Mutagenesis·Bambarendage P U PereraDana C Dolinoy
Nov 22, 2019·Frontiers in Molecular Biosciences·Kuldeep DhamaSunil Kumar Joshi
Jul 25, 2021·International Journal of Molecular Sciences·Caterina FormichiFrancesco Dotta

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Methods Mentioned

BETA
antisense oligonucleotides
xenograft
chemical modification

Clinical Trials Mentioned

NCT01200420
NCT01829971

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