A general program to estimate gene-frequencies by the method of maximum-likelihood

Computer Programs in Biomedicine
M Jainz

Abstract

The program estimates the optimal gene-frequencies from observed values of phenotypes by the method of maximum-likelihood. The program does not make assumptions about a specific blood-group-system. This information has to be supplied by input cards. A straightforward iteration process is used for obtaining initial estimates for the gene-frequencies in question. Then an iterative application of the Newton-Raphson method is used to solve the maximum-likelihood equations. The program yields the gene-frequencies and their standard deviations, expected values of the phenotypes, expected values of the genotypes. Finally the chi-square between observed frequencies and (optimal) expected values of phenotypes is computed.

Citations

Nov 1, 1988·Computer Methods and Programs in Biomedicine·C E Kahn
Feb 21, 2009·BMC Bioinformatics·Zhaoxia YuDaniel J Schaid
Apr 9, 2008·PLoS Computational Biology·Jennifer ListgartenDavid Heckerman
Apr 1, 1990·Multivariate Behavioral Research·D Kaplan
Apr 1, 1990·Multivariate Behavioral Research·D Kaplan
Mar 17, 2006·International Journal of Biometeorology·Igor Knez, Sofia Thorsson
Mar 1, 2007·Animal : an International Journal of Animal Bioscience·C M R de MeloP F Machado
Jan 1, 1983·Biological cybernetics·S C CannonS Shamma

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