A General Theoretical Framework to Study the Influence of Electrical Fields on Mesenchymal Stem Cells

Frontiers in Bioengineering and Biotechnology
Jonathan DawsonRevathi Appali

Abstract

Mesenchymal stem cell dynamics involve cell proliferation and cell differentiation into cells of distinct functional type, such as osteoblasts, adipocytes, or chondrocytes. Electrically active implants influence these dynamics for the regeneration of the cells in damaged tissues. How applied electric field influences processes of individual stem cells is a problem mostly unaddressed. The mathematical approaches to study stem cell dynamics have focused on the stem cell population as a whole, without resolving individual cells and intracellular processes. In this paper, we present a theoretical framework to describe the dynamics of a population of stem cells, taking into account the processes of the individual cells. We study the influence of the applied electric field on the cellular processes. We test our mean-field theory with the experiments from the literature, involving in vitro electrical stimulation of stem cells. We show that a simple model can quantitatively describe the experimentally observed time-course behavior of the total number of cells and the total alkaline phosphate activity in a population of mesenchymal stem cells. Our results show that the stem cell differentiation rate is dependent on the applied electrica...Continue Reading

References

Sep 1, 1988·IEEE Transactions on Bio-medical Engineering·C E Miller, C S Henriquez
May 1, 1993·Journal of Cellular Biochemistry·D M Ciombor, R K Aaron
Oct 29, 2000·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·C H LohmannB D Boyan
Mar 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Thiruvallur R Gowrishankar, James C Weaver
Apr 18, 2003·Bioelectrochemistry·Airton RamosJefferson L B Marques
Apr 25, 2003·European Biophysics Journal : EBJ·Blaz ValicDamijan Miklavcic
Jun 29, 2004·Bioelectrochemistry·J L SebastiánJ M Miranda
Aug 10, 2004·Bioelectromagnetics·Walter Hong-Shong ChangFeng-Huei Lin
Aug 23, 2006·Cell·Adam J EnglerDennis E Discher
Feb 13, 2007·Annual Review of Biophysics and Biomolecular Structure·Smadar Ben-Tabou de-Leon, Eric H Davidson
Apr 5, 2007·IEEE Transactions on Bio-medical Engineering·Wenjun Ying, Craig S Henriquez
Dec 11, 2007·Biophysical Journal·Vijayanand VajralaJohn H Miller
Apr 12, 2008·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Z SchwartzB D Boyan
Aug 1, 2008·Computational Biology and Chemistry·Massimo PisuGiacomo Cao
Dec 31, 2008·Physical Review Letters·Aparna Baskaran, M Cristina Marchetti
Dec 1, 1992·Biophysical Journal·C Grosse, H P Schwan
Oct 20, 2009·Indian Journal of Orthopaedics·Paul Rt Kuzyk, Emil H Schemitsch
Dec 8, 2009·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Nina TandonGordana Vunjak-Novakovic
Jun 10, 2010·PloS One·Peter D TongePeter W Andrews
Oct 19, 2010·Medical & Biological Engineering & Computing·Mohammad A TabatabaiKaran P Singh
Sep 11, 2012·Mathematical Biosciences·Zheng Sun, Natalia L Komarova
Feb 7, 2014·Proceedings of the National Academy of Sciences of the United States of America·Jinzhi LeiQing Nie
Mar 5, 2014·Proceedings of the National Academy of Sciences of the United States of America·Ben D MacArthur
Jul 19, 2014·Bulletin of Mathematical Biology·Przemysław Rafał Paździorek
Oct 17, 2014·Journal of Mathematical Biology·Zheng Sun, Natalia L Komarova
Dec 17, 2014·Proceedings of the National Academy of Sciences of the United States of America·P C Dave P DingalDennis E Discher
May 2, 2015·PloS One·Seyed Jamaleddin Mousavi, Mohamed Hamdy Doweidar
May 3, 2015·Journal of Theoretical Biology·Steven J LadeThilo Gross
May 20, 2015·Integrative Biology : Quantitative Biosciences From Nano to Macro·T A BanksJ J Cooper-White
Jun 2, 2015·Frontiers in Physiology·Richard H W Funk
Jun 16, 2015·Mathematical Biosciences·Jienian YangNatalia L Komarova
Jan 23, 2016·Soft Matter·Pierre RechoPhilippe Marcq
Sep 27, 2016·Medical Science Monitor Basic Research·Arkady RutkovskiyIngvar Jarle Vaage
Oct 30, 2016·International Journal of Stem Cells·Mahtab Maghzi NajafabadiForouzan Absalan

❮ Previous
Next ❯

Software Mentioned

COMSOL Multiphysics

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.