Mar 24, 2015

A General Theory of Differentiated Multicellularity

BioRxiv : the Preprint Server for Biology
Felipe A. Veloso

Abstract

Scientists agree that changes in the levels of gene expression are important for the cell differentiation process. Research in the field has customarily assumed that such changes regulate this process when they interconnect in space and time by means of complex epigenetic mechanisms. In fundamental terms, however, this assumed regulation refers only to the intricate propagation of changes in gene expression or else leads to logical inconsistencies. The evolution and intrinsic regulatory dynamics of differentiated multicellularity also lack a unified and falsifiable description. To fill this gap, I analyzed publicly available high-throughput data of histone H3 post-translational modifications and mRNA abundance for different Homo sapiens , Mus musculus , and Drosophila melanogaster cell-type/developmental-period samples. An analysis of genomic regions adjacent to transcription start sites generated for each cell-type/developmental-period dataset a profile from pairwise partial correlations between histone modifications controlling for the respective mRNA levels. Here I report that these profiles, while explicitly uncorrelated to transcript abundance by construction, associate strongly with cell differentiation states. This assoc...Continue Reading

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Mentioned in this Paper

Research
Multicellular Organismal Development
Biological Regulation
Genome
Post-Translational Protein Processing
Regulation of Biological Process
Transcription Initiation Site
Transcription, Genetic
Regulation of Intrinsic Apoptosis
Extracellular Space

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