A generic minimization random allocation and blinding system on web

Journal of Biomedical Informatics
Hong Wei CaiYongping Yan

Abstract

Minimization is a dynamic randomization method for clinical trials. Although recommended by many researchers, the utilization of minimization has been seldom reported in randomized trials mainly because of the controversy surrounding the validity of conventional analyses and its complexity in implementation. However, both the statistical and clinical validity of minimization were demonstrated in recent studies. Minimization random allocation system integrated with blinding function that could facilitate the implementation of this method in general clinical trials has not been reported. SYSTEM OVERVIEW: The system is a web-based random allocation system using Pocock and Simon minimization method. It also supports multiple treatment arms within a trial, multiple simultaneous trials, and blinding without further programming. This system was constructed with generic database schema design method, Pocock and Simon minimization method and blinding method. It was coded with Microsoft Visual Basic and Active Server Pages (ASP) programming languages. And all dataset were managed with a Microsoft SQL Server database. Some critical programming codes were also provided. SIMULATIONS AND RESULTS: Two clinical trials were simulated simultaneo...Continue Reading

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Citations

Mar 6, 2009·European Journal of Clinical Pharmacology·Chanjuan LiGuanquan Chen
Jan 12, 2012·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·X LiuG Zhao
Jul 23, 2013·Journal of Medical Internet Research·Lan XiaoJun Ma
Jan 23, 2016·Journal of Clinical Psychology·Helané WahbehBarry S Oken
Mar 16, 2013·International Journal of Stroke : Official Journal of the International Stroke Society·Xuedong LiuGang Zhao
Apr 5, 2014·Computational and Mathematical Methods in Medicine·Yan CuiShizhong Liao
Jun 26, 2012·Computer Methods and Programs in Biomedicine·Lan XiaoJun Ma

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