PMID: 109079Dec 1, 1978

A genetic and developmental analysis of an acid deoxyribonuclease in Drosophila melanogaster

Biochemical Genetics
C Detwiler, R J MacIntyre


A deoxyribonuclease, called D Nase-1, that is active at acid pH in the presence of EDTA has been studied in Drosophila melanogaster. The locus for the Enzyme maps genetically to 61.8 on the right arm of the third chromosome. Cytogenetically, DNase-1 has been localized to within five to ten bands between 90C-2 and 90E. This analysis utilizes both electrophoretic variants and the Y-autosome translocations of Lindsley et al. (1972). DNase-1 is present in all stages of the life cycle, and the paternal genome actively contributes DNase-1 to the ambryo between 0 and 1 hr after fertilization.


May 16, 1975·Biochimica Et Biophysica Acta·S Bacchetti, R Benne
May 1, 1977·Cell·A ChovnickM McCarron
Mar 1, 1978·Developmental Biology·R YasbinR J MacIntyre
Mar 1, 1976·Analytical Biochemistry·N Matsokis, J G Georgatsos
Jan 1, 1976·Annual Review of Genetics·R J MacIntyre, S J O'Brien
Jan 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·J J Champoux, R Dulbecco
Aug 1, 1968·Canadian Journal of Biochemistry·C Cordonnier, G BERNARDI
Feb 1, 1966·The Journal of Cell Biology·F A Muckenthaler, A P Mahowald
Apr 18, 1966·Biochimica Et Biophysica Acta·M Matsuda, H Ogoshi
Aug 1, 1953·Biochimica Et Biophysica Acta·L CUNNINGHAM, M LASKOWSKI
Dec 1, 1959·The Biochemical Journal·H BEAUFAY, C DE DUVE


Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A M BurnellJ Doherty
Dec 4, 2003·Gene·Cory J Evans, Renato J Aguilera
Sep 21, 2002·Gene·Cory J EvansRenato J Aguilera
Aug 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·James A Birchler, Reiner A Veitia
Apr 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lin SunJames A Birchler
Feb 21, 2013·Seminars in Cell & Developmental Biology·James A Birchler
Feb 10, 2010·The Biochemical Journal·James A Birchler
Aug 29, 2014·PLoS Neglected Tropical Diseases·Chengshui LiaoXiaolei Liu
Dec 29, 1978·Journal of Molecular Evolution·R J MacIntyreG Batt
May 1, 1982·Quarterly Reviews of Biophysics·J C Hall

Related Concepts

Genome Mapping
Alkaline DNase
Drosophila melanogaster
Biological Metamorphosis

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Systemic Juvenile Idiopathic Arthritis

Systemic juvenile idiopathic arthritis is a rare rheumatic disease that affects children. Symptoms include joint pain, but also fevers and skin rashes. Here is the latest on this disease.

Chromatin Regulation and Circadian Clocks

The circadian clock plays an important role in regulating transcriptional dynamics through changes in chromatin folding and remodelling. Discover the latest research on Chromatin Regulation and Circadian Clocks here.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.

Pontocerebellar Hypoplasia

Pontocerebellar hypoplasias are a group of neurodegenerative autosomal recessive disorders with prenatal onset, atrophy or hypoplasia of the cerebellum, hypoplasia of the ventral pons, microcephaly, variable neocortical atrophy and severe mental and motor impairments. Here is the latest research on pontocerebellar hypoplasia.

Cell Atlas Along the Gut-Brain Axis

Profiling cells along the gut-brain axis at the single cell level will provide unique information for each cell type, a three-dimensional map of how cell types work together to form tissues, and insights into how changes in the map underlie health and disease of the GI system and its crosstalk with the brain. Disocver the latest research on single cell analysis of the gut-brain axis here.

Chronic Traumatic Encephalopathy

Chronic Traumatic Encephalopathy (CTE) is a progressive degenerative disease that occurs in individuals that suffer repetitive brain trauma. Discover the latest research on traumatic encephalopathy here.