PMID: 109079Dec 1, 1978

A genetic and developmental analysis of an acid deoxyribonuclease in Drosophila melanogaster

Biochemical Genetics
C Detwiler, R J MacIntyre

Abstract

A deoxyribonuclease, called D Nase-1, that is active at acid pH in the presence of EDTA has been studied in Drosophila melanogaster. The locus for the Enzyme maps genetically to 61.8 on the right arm of the third chromosome. Cytogenetically, DNase-1 has been localized to within five to ten bands between 90C-2 and 90E. This analysis utilizes both electrophoretic variants and the Y-autosome translocations of Lindsley et al. (1972). DNase-1 is present in all stages of the life cycle, and the paternal genome actively contributes DNase-1 to the ambryo between 0 and 1 hr after fertilization.

References

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Citations

Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·A M BurnellJ Doherty
Dec 4, 2003·Gene·Cory J Evans, Renato J Aguilera
Sep 21, 2002·Gene·Cory J EvansRenato J Aguilera
Aug 22, 2012·Proceedings of the National Academy of Sciences of the United States of America·James A Birchler, Reiner A Veitia
Apr 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Lin SunJames A Birchler
Feb 21, 2013·Seminars in Cell & Developmental Biology·James A Birchler
Feb 10, 2010·The Biochemical Journal·James A Birchler
Aug 29, 2014·PLoS Neglected Tropical Diseases·Chengshui LiaoXiaolei Liu
Dec 29, 1978·Journal of Molecular Evolution·R J MacIntyreG Batt
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Related Concepts

Metazoa
Genome Mapping
Alkaline DNase
Drosophila melanogaster
SDS-PAGE
Cistron
Biological Metamorphosis

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