PMID: 9192162Jun 1, 1997Paper

A genetic basis for corneal sensitivity to ultraviolet light among recombinant SWXJ inbred strains of mice

Current Eye Research
J E DownesR S Holmes

Abstract

To examine a possible genetic basis for corneal sensitivity to UV-B light exposure. To this end, adult male mice from the 14 SWXJ recombinant inbred albino strains (originating from SJL/J and SWR/J parental strains) were subjected to ultraviolet (UV) radiation exposure of 0.078 J/cm2 and photographed four days post-exposure, to assess corneal opacity and the possible correlation with corneal aldehyde dehydrogenase (ALDH) activity, alcohol dehydrogenase (ADH) activity and soluble protein content. Those recombinant strains that exhibited the SWR/J strain phenotype of having low levels of ALDH and decreased soluble protein levels also exhibited greater levels of corneal clouding after UV-exposure than the other strains, which exhibited "normal" levels of both ALDH activity and soluble protein in the cornea. These data support an hypothesis for a major role for ALDH in assisting the cornea to protect the eye against UV-induced tissue damage.

References

Oct 1, 1977·Analytica Chimica Acta·M I KarayannisC P Gousetis
Jun 1, 1990·Optometry and Vision Science : Official Publication of the American Academy of Optometry·J P Bergmanson
Feb 1, 1989·Photochemistry and Photobiology·M J Doughty, A P Cullen
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Apr 1, 1971·American Industrial Hygiene Association Journal·D G Pitts, T J Tredici
Jan 1, 1984·Current Eye Research·L I Grossweiner
Dec 1, 1983·European Journal of Biochemistry·E M AlgarR S Holmes
Jul 1, 1984·American Journal of Optometry and Physiological Optics·A P CullenS E Jany
Jul 1, 1996·Experimental Eye Research·L UmaD Balasubramanian
Jun 1, 1946·Archives of Ophthalmology·D G COGAN, V E KINSEY

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Citations

Oct 19, 2007·Toxicologic Pathology·Kimberly M NewkirkDonna F Kusewitt
Feb 19, 2002·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Rajeev BuddiDonald J Brown
Mar 3, 2017·BioMed Research International·Mariam Lotfy KhaledYutao Liu
Mar 5, 2003·Journal of Biochemical and Molecular Toxicology·Norman E Sládek
Jan 25, 2007·Molecular BioSystems·Daniel ConklinAruni Bhatanagar
Apr 18, 2001·Chemico-biological Interactions·A PappaV Vasiliou
Jan 13, 2001·Chemico-biological Interactions·V VasiliouD R Petersen
Feb 27, 2003·Chemico-biological Interactions·Rizwan ManzerVasilis Vasiliou

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