A genetic dissection of breed composition and performance enhancement in the Alaskan sled dog.

BMC Genetics
Heather J HusonElaine A Ostrander

Abstract

The Alaskan sled dog offers a rare opportunity to investigate the development of a dog breed based solely on performance, rather than appearance, thus setting the breed apart from most others. Several established breeds, many of which are recognized by the American Kennel Club (AKC), have been introduced into the sled dog population to enhance racing performance. We have used molecular methods to ascertain the constitutive breeds used to develop successful sled dog lines, and in doing so, determined the breed origins of specific performance-related behaviors.One hundred and ninety-nine Alaskan sled dogs were genotyped using 96 microsatellite markers that span the canine genome. These data were compared to that from 141 similarly genotyped purebred dog breeds. Sled dogs were evaluated for breed composition based on a variety of performance phenotypes including speed, endurance and work ethic, and the data stratified based on population structure. We observe that the Alaskan sled dog has a unique molecular signature and that the genetic profile is sufficient for identifying dogs bred for sprint versus distance. When evaluating contributions of existing breeds we find that the Alaskan Malamute and Siberian Husky contributions are ...Continue Reading

References

Jun 13, 1997·Science·C VilàR K Wayne
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Citations

Nov 23, 2011·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Heather J HusonElaine A Ostrander
Jan 25, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Robert K Wayne, Bridgett M vonHoldt
Jan 11, 2012·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Heidi G Parker
Nov 5, 2010·Annual Review of Genetics·Heidi G ParkerElaine A Ostrander
Jan 9, 2014·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·E Ceh, P Dovc
Nov 5, 2016·The Journal of Experimental Biology·Caleb M Bryce, Terrie M Williams
Jul 13, 2018·Medicine and Science in Sports and Exercise·Michael S DavisKatherine K Williamson
Jul 18, 2014·The Journal of Veterinary Medical Science·Eun-Woo LeeGil-Jae Cho
Sep 24, 2020·Expert Opinion on Therapeutic Targets·Andreia Neves-CarvalhoPatrícia Maciel
Aug 19, 2017·The Journal of Veterinary Medical Science·Genya ShimboKazuro Miyahara
Jul 5, 2018·Proceedings of the National Academy of Sciences of the United States of America·Jaemin KimElaine A Ostrander
Oct 3, 2018·Journal of the American Veterinary Medical Association·Dirsko J F von PfeilBryden J Stanley
Dec 30, 2020·Canine Medicine and Genetics·Kim K L Bellamy, Frode Lingaas
Sep 22, 2021·Canine Medicine and Genetics·Joseph A Thorsrud, Heather J Huson

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Methods Mentioned

BETA
electrophoresis
genotyping

Software Mentioned

GDA
Genetic Data Analysis ( GDA )
Sigma
STRUCTURE

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