A Genetic Investigation of the Well-Being Spectrum.

Behavior Genetics
Bart M L BaselmansMeike Bartels

Abstract

The interrelations among well-being, neuroticism, and depression can be captured in a so-called well-being spectrum (3-phenotype well-being spectrum, 3-WBS). Several other human traits are likely linked to the 3-WBS. In the present study, we investigate how the 3-WBS can be expanded. First, we constructed polygenic risk scores for the 3-WBS and used this score to predict a series of traits that have been associated with well-being in the literature. We included information on loneliness, big five personality traits, self-rated health, and flourishing. The 3-WBS polygenic score predicted all the original 3-WBS traits and additionally loneliness, self-rated health, and extraversion (R2 between 0.62% and 1.58%). Next, using LD score regression, we calculated genetic correlations between the 3-WBS and the traits of interest. From all candidate traits, loneliness and self-rated health were found to have the strongest genetic correlations (rg = - 0.79, and rg= 0.64, respectively) with the 3-WBS. Lastly, we use Genomic SEM to investigate the factor structure of the proposed spectrum. The best model fit was obtained for a two-factor model including the 5-WBS traits, with two highly correlated factors representing the negative- and posi...Continue Reading

References

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Citations

Jan 18, 2020·Depression and Anxiety·Genevieve Morneau-VaillancourtThalia C Eley
Sep 16, 2020·World Psychiatry : Official Journal of the World Psychiatric Association (WPA)·Irwin D WaldmanJingjing Yang
Apr 2, 2020·Nature Neuroscience·Sandra Sanchez-Roige, Abraham A Palmer
Nov 13, 2020·Progress in Neuro-psychopharmacology & Biological Psychiatry·Giuseppe FanelliChiara Fabbri
May 25, 2021·European Child & Adolescent Psychiatry·Margot P van de WeijerMeike Bartels
Jun 1, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Janita BraltenGeert Poelmans

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Methods Mentioned

BETA
genotyping
chip

Software Mentioned

gee
Genomic SEM
package
LDpred
Affymetrix Contrast
PLINK
R
package Psychometrics

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