A genetic mechanism implicates chromosome 11 in schizophrenia and bipolar diseases

Genetics
Amar J S Klar

Abstract

The causes of schizophrenia and bipolar human psychiatric disorders are unknown. A novel somatic cell genetic model postulated nonrandom segregation of "Watson" vs. "Crick" DNA chains of both copies of a chromosome to specific daughter cells. Such an oriented asymmetric cell division causes development of healthy, functionally nonequivalent brain hemispheres. Genetic translocations of the chromosome may cause disease by disrupting the biased strand-segregation process. Only one-half of chromosome 1 and 11 translocation carriers developing disease were recently explained as a result consistent with the model (Klar 2002). Is chromosome 1 or 11 involved? Does the translocation breakpoint cause disease? Remarkably, two other unrelated chromosome 11 translocations discovered from the literature likewise caused disease in approximately 50% of carriers. Together, their breakpoints lie at three distinct regions spanning approximately 40% of chromosome 11. Thus, chromosome 11 is implicated but the breakpoints themselves are unlikely to cause the disease. The results suggest that the genetically caused disease develops without a Mendelian gene mutation.

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Citations

May 18, 2013·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Amar J S Klar, Michael J Bonaduce
Feb 24, 2006·European Journal of Human Genetics : EJHG·Maria Karayiorgou, Joseph A Gogos
Aug 25, 2005·Cold Spring Harbor Symposia on Quantitative Biology·A J S Klar
Jan 10, 2008·Annual Review of Cell and Developmental Biology·Shahragim TajbakhshIsabelle Le Roux
Aug 28, 2007·Genetics·Gurjeet Singh, Amar J S Klar
Jan 29, 2008·Psychiatry Research·Laurence Borras, Philippe Huguelet
Jul 17, 2013·Asia-Pacific Psychiatry : Official Journal of the Pacific Rim College of Psychiatrists·Jianliang NiChen Zhang
Dec 13, 2005·Medical Hypotheses·Jeff S Hatfield
Nov 11, 2008·Current Opinion in Cell Biology·Shahragim Tajbakhsh
Nov 9, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Amar J S Klar
Feb 25, 2006·Science·Athanasios Armakolas, Amar J S Klar
Jan 6, 2007·Science·Athanasios Armakolas, Amar J S Klar

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