A genetic model for multimorbidity in young adults

Genetics in Medicine : Official Journal of the American College of Medical Genetics
Sarah L VollAnne S Bassett

Abstract

Multimorbidity is increasing in younger adults but is understudied in this population. We used 22q11.2 deletion syndrome (22q11.2DS) as a genetic model to investigate multimorbidity in young to middle-aged adults. Using the Anatomical Therapeutic Chemical (ATC) Classification System and setting five or more concurrent prescription medications as a proxy for multimorbidity, we compared data on 264 adults with 22q11.2DS (median age 27.8, range 17.3-68.3 years) with that for a community-based Canadian general population sample (n = 25,287). We used logistic regression to examine possible predictors of multimorbidity in 22q11.2DS. Multimorbidity in 22q11.2DS in the 25-44 year age group (34.7%) was significantly more prevalent than in the general population, both for the same age group (2.9%, prevalence ratio [PR] = 11.9, 95% CI 8.4-17.1) and compared with those aged 45-64 years (16.4%, PR = 2.1, 95% CI 1.6-2.7). Neuropsychiatric and endocrinological medication classes predominated. Within 22q11.2DS, older age and psychotic illness, but not sex, major congenital heart disease, or intellectual disability, were significant predictors of multimorbidity. The results indicate that adults with 22q11.2DS have a significant burden of illnes...Continue Reading

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Citations

May 15, 2020·Journal of Applied Research in Intellectual Disabilities : JARID·Joanne C Y LooAnne S Bassett
Jan 9, 2021·Revista Panamericana De Salud Pública = Pan American Journal of Public Health·Julián A Fernández-NiñoAlvaro J Idrovo
Feb 25, 2021·Current Psychiatry Reports·Ania M FiksinskiJacob A S Vorstman

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22q11 Deletion Syndrome

22q11.2 deletion syndrome, also known as DiGeorge syndrome, is a congenital disorder caused by a partial deletion of chromosome 22. Symptoms include heart defects, poor immune system function, a cleft palate, complications related to low levels of calcium in the blood, and delayed development. Discover the latest research on this disease here.

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