A genetic model of the effects of insecticide-treated bed nets on the evolution of insecticide-resistance

Evolution, Medicine, and Public Health
Philip L G Birget, Jacob C Koella

Abstract

The evolution of insecticide-resistance in malaria vectors is emerging as a serious challenge for the control of malaria. Modelling the spread of insecticide-resistance is an essential tool to understand the evolutionary pressures and dynamics caused by the application of insecticides. We developed a population-genetic model of the spread of insecticide-resistance in a population of Anopheles vectors in response to insecticides used either as adulticides (focussing on insecticide-treated bed nets (ITNs)) or as larvicides (either for the control of malaria or, as an inadvertent side-product, in agriculture). We show that indoor use of insecticides leads to considerably less selection pressure than their use as larvicides, supporting the idea that most resistance of malaria vectors is due to the agricultural use of the insecticides that are also used for malaria control. The reasons for the relatively low selection pressure posed by adulticides are (i) that males are not affected by the ITNs and, in particular, (ii) that the insecticides are also repellents, keeping mosquitoes at bay from contacting the insecticide but also driving them to bite either people who do not use the insecticide or alternative hosts. We conclude by disc...Continue Reading

References

Jul 21, 1998·Science·D N Nabarro, E M Tayler
Dec 16, 1998·Transactions of the Royal Society of Tropical Medicine and Hygiene·M L QuiñonesB M Greenwood
Feb 18, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·C F CurtisI Kasumba
Apr 27, 2002·Genetical Research·Claire BerticatChristine Chevillon
Jan 10, 2003·The American Journal of Tropical Medicine and Hygiene·Abdoulaye DiabateJean Marc Hougard
Mar 28, 2006·Malaria Journal·Martin C AkogbétoDorothée A Kindé-Gazard
Apr 10, 2009·PLoS Biology·Andrew F ReadMatthew B Thomas
Mar 30, 2010·The American Journal of Tropical Medicine and Hygiene·Katrijn VerhaeghenMarc Coosemans
Nov 5, 2011·Malaria Journal·Michael T WhiteAzra C Ghani
Apr 5, 2013·Evolution; International Journal of Organic Evolution·Michelle L GattonSteve W Lindsay
Mar 25, 2014·Mathematical Biosciences·Kbenesh W Blayneh, Jemal Mohammed-Awel
May 14, 2014·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Janet Hemingway
Nov 1, 2009·Evolutionary Applications·Jacob C KoellaAndrew F Read
Apr 1, 2012·Evolutionary Applications·Jacob C KoellaThomas P S Karacs

❮ Previous
Next ❯

Citations

Apr 11, 2018·Evolutionary Applications·Silvie Huijben, Krijn P Paaijmans
Jul 11, 2018·Malaria Journal·Chris Stone, Kevin Gross
May 25, 2020·Journal of Mathematical Biology·Iboi EnahoroKrijn Paaijmans
Jul 16, 2019·Journal of Biological Dynamics·Juhua LiangRobert A Cheke

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.