A genetic mouse model of helplessness sensitive to imipramine

European Journal of Pharmacology
J M VaugeoisJean Costentin

Abstract

Lines of mice were selectively bred to diverge in their spontaneous helplessness in the tail suspension test. By the second generation of selection, only mice of the helpless line were sensitive to the antidepressant imipramine. Genetic factors substantially contribute to the susceptibility to helplessness in this mouse model. These selectively bred lines may represent potentially useful animal models to investigate behavioural, neurochemical and neuroendocrine correlates of antidepressant action.

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Citations

Jul 10, 2007·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Heena V LadLeonard C Schalkwyk
May 12, 2005·Neuroscience and Biobehavioral Reviews·Adrian J DunnRenaud de Beaurepaire
Jul 5, 2003·Biological Psychiatry·John F CryanAthina Markou
Mar 20, 2002·Pharmacology, Biochemistry, and Behavior·Jean-Claude Do-RegoJean Costentin
May 15, 2002·Trends in Pharmacological Sciences·John F CryanIrwin Lucki
Aug 25, 2000·Progress in Neuro-psychopharmacology & Biological Psychiatry·R Andreatini, L F Bacellar
May 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Malika El YacoubiJean-Marie Vaugeois
Aug 18, 2004·Annales pharmaceutiques françaises·J-M VaugeoisJ Costentin
Apr 3, 2016·Behavioural Brain Research·Aislinn J WilliamsHisashi Umemori
Nov 1, 2011·Neuroscience and Biobehavioral Reviews·Thibault RenoirLaurence Lanfumey
Oct 20, 2006·Pharmacology, Biochemistry, and Behavior·Grzegorz R JuszczakArtur H Swiergiel
Feb 25, 2006·Behavioural Brain Research·Jean-Claude do-RegoJean Costentin
Mar 26, 2004·Nature Reviews. Drug Discovery·Ma-Li Wong, Julio Licinio
Mar 15, 2000·Reviews in the Neurosciences·R D Porsolt
Apr 5, 2011·Current Protocols in Neuroscience·Vincent CastagnéRoger D Porsolt
Jun 1, 2010·Current Protocols in Pharmacology·Vincent CastagnéRoger D Porsolt
Oct 22, 2019·Communications Biology·Melanie D MarkStefan Herlitze
Jan 12, 2020·Communications Biology·Melanie D MarkStefan Herlitze

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