A genetic regulatory network for Xenopus mesendoderm formation

Developmental Biology
Matthew Loose, Roger K Patient

Abstract

We have constructed a genetic regulatory network (GRN) summarising the functional relationships between the transcription factors (TFs) and embryonic signals involved in Xenopus mesendoderm formation. It is supported by a relational database containing the experimental evidence and both are available in interactive form via the World Wide Web. This network highlights areas for further study and provides a framework for systematic interrogation of new data. Comparison with the equivalent network for the sea urchin identifies conserved features of the deuterostome ancestral pathway, including positive feedback loops, GATA factors, SoxB, Brachyury and a previously underemphasised role for beta-catenin. In contrast, some features central to one species have not yet been found in the other, for example, Krox and Otx in sea urchin, and Mix and Nodal in Xenopus. Such differences may represent evolved features or may eventually be resolved. For example, in Xenopus, Nodal-related genes are positively regulated by beta-catenin and at least one of them is repressed by Sox3, as is the uncharacterised early signal (ES) inducing endomesoderm in the sea urchin, suggesting that ES may be a Nodal-like TGF-beta. Wider comparisons of such network...Continue Reading

References

Jan 1, 1995·Current Biology : CB·S Schulte-Merker, J C Smith
Apr 15, 1997·Developmental Biology·E M Joseph, D A Melton
Jul 4, 1998·Science·G L Henry, D A Melton
Sep 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·P E MeadL I Zon
Apr 13, 2000·Proceedings of the National Academy of Sciences of the United States of America·S A ShoichetR A Shivdasani
Apr 27, 2000·Mechanisms of Development·Y SakaJ C Smith
Jul 13, 2000·Current Opinion in Genetics & Development·D Kimelman, K J Griffin
Aug 31, 2000·Developmental Biology·A Erives, M Levine
May 5, 2001·Cell·A Rodaway, R Patient
Dec 26, 2001·Bioinformatics·S KumarM Nei
Jan 11, 2002·Developmental Biology·Yasuko OnumaMakoto Asashima
Jan 24, 2002·Mechanisms of Development·Catherine PapinJames C Smith
Mar 2, 2002·Science·Eric H DavidsonHamid Bolouri
May 25, 2002·Developmental Biology·Eric H DavidsonHamid Bolouri
Jul 9, 2002·Current Opinion in Genetics & Development·Roger K Patient, James D McGhee
Sep 11, 2002·Developmental Biology·Ramesh A Shivdasani
Dec 20, 2002·Developmental Biology·Minako K Hashimoto-PartykaKen W Y Cho
Jul 4, 2003·The EMBO Journal·Anne Schohl, François Fagotto
Aug 19, 2003·Developmental Biology·Sylvain MarcelliniPatrick Lemaire
Nov 5, 2003·Proceedings of the National Academy of Sciences of the United States of America·Veronica F HinmanEric H Davidson

❮ Previous
Next ❯

Citations

Apr 24, 2014·Development·Clara CollartMichael J Gilchrist
Jan 14, 2011·Reproduction : the Official Journal of the Society for the Study of Fertility·Andrew D JohnsonBrian I Crother
Apr 12, 2014·Science·Teri EvansMatthew Loose
Mar 30, 2005·Proceedings of the National Academy of Sciences of the United States of America·Tetsuya KoideKen W Y Cho
May 12, 2009·Cell Stem Cell·Tariq EnverPeter W Andrews
Jun 10, 2010·Zoological Science·Yuka OkamitsuNaoaki Sakamoto
Aug 8, 2006·Genome Biology·Fiona C WardleJames C Smith
Jul 26, 2008·Proteome Science·Wolfgang E Reintsch, Craig A Mandato
Feb 20, 2009·Proceedings of the National Academy of Sciences of the United States of America·Rosalind H MorleyFiona C Wardle
Apr 21, 2009·The International Journal of Developmental Biology·Isabelle S Peter, Eric H Davidson
Jul 7, 2009·Annual Review of Cell and Developmental Biology·Aaron M Zorn, James M Wells
Jan 13, 2010·Cold Spring Harbor Perspectives in Biology·James C Smith
Mar 30, 2010·BMC Developmental Biology·Chung-Hao ChaoChiou-Hwa Yuh
Jul 1, 2011·Development·Jianli ShiMichael W Klymkowsky
Apr 14, 2007·Development Genes and Evolution·Cesar Arenas-Mena, Kimberly Suk-Ying Wong
May 12, 2011·Integrative and Comparative Biology·Jonathan Q HenryMark Q Martindale
Feb 20, 2016·Wiley Interdisciplinary Reviews. Developmental Biology·Michael J LaydenEric Röttinger
Oct 12, 2012·Experimental Cell Research·Zhongwei Li, Ye-Guang Chen
Nov 11, 2008·Biochimica Et Biophysica Acta·Tzu-Min ChanChiou-Hwa Yuh
Sep 10, 2008·Biochimica Et Biophysica Acta·Morris F Maduro
Jun 11, 2008·Journal of Theoretical Biology·Akihiko Nakajima, Kunihiko Kaneko
Sep 14, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Ann Foley
Jun 24, 2008·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Joly KwekMary Familari
Jan 18, 2007·Evolution & Development·William J GillisStephan Q Schneider
Feb 26, 2008·The British Journal of Dermatology·A Bewley, UNKNOWN Dermatology Working Group
Sep 11, 2010·Wiley Interdisciplinary Reviews. Systems Biology and Medicine·Wenrui Liu, Ann C Foley
Nov 24, 2012·Genesis : the Journal of Genetics and Development·Andrea StreitClaudio D Stern
Sep 29, 2012·Evolution & Development·Nori SatohHiroki Takahashi
Oct 1, 2009·Molecular Reproduction and Development·Ben Ewen-CampenCassandra G M Extavour
Jan 22, 2005·Seminars in Cell & Developmental Biology·Tessa PeterkinRoger Patient
Dec 17, 2005·Seminars in Cell & Developmental Biology·Fiona C Wardle, James C Smith
Jul 23, 2015·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kimberly J PerryJonathan Q Henry
Oct 24, 2009·Developmental Biology·Audrey HoltzingerTodd Evans
Oct 6, 2009·Developmental Biology·Oliver NentwichJ C Smith
Dec 9, 2008·Developmental Biology·Claire L Salzer, Justin P Kumar
Feb 20, 2007·Mechanisms of Development·Anne Grapin-Botton, Daniel Constam

❮ Previous
Next ❯

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