A Genetic Risk Score for Atrial Fibrillation Predicts the Response to Catheter Ablation

Korean Circulation Journal
Won Seok ChoeHong Euy Lim

Abstract

The association of susceptibility loci for atrial fibrillation (AF) with AF recurrence after ablation has been reported, although with controversial results. In this prospective cohort analysis, we aimed to investigate whether a genetic risk score (GRS) can predict the rhythm outcomes after catheter ablation of AF. We determined the association between 20 AF-susceptible single nucleotide polymorphisms (SNPs) and AF recurrence after catheter ablation in 746 patients (74% males; age, 59±11 years; 56% paroxysmal AF). A GRS was calculated by summing the unweighted numbers of risk alleles of selected SNPs. A Cox proportional hazard model was used to identify the association between the GRS and risk of AF recurrence after catheter ablation. AF recurrences after catheter ablation occurred in 168 (22.5%) subjects with a median follow-up of 23 months. The GRS was calculated using 5 SNPs (rs1448818, rs2200733, rs6843082, rs6838973 at chromosome 4q25 [PITX2] and rs2106261 at chromosome 16q22 [ZFHX3]), which showed modest associations with AF recurrence. The GRS was significantly associated with AF recurrence (hazard ratio [HR] per each score, 1.13; 95% confidence interval [CI], 1.03-1.24). Patients with intermediate (GRS 4-6) and high ris...Continue Reading

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Citations

Sep 26, 2019·Frontiers in Cardiovascular Medicine·Silje Madeleine KalstøIngrid E Christophersen
Feb 27, 2019·Korean Circulation Journal·Chin Yu LinShih Ann Chen
Jan 14, 2021·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Rosa Doñate PuertasPhilippe Chevalier
Mar 9, 2021·Expert Review of Cardiovascular Therapy·Sanghamitra MohantyAndrea Natale
Apr 6, 2021·Current Opinion in Cardiology·Jitae A KimNa Li

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Methods Mentioned

BETA
genotyping

Software Mentioned

SDS
SPSS Statistics

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