A genetic test of the role of the maternal pronucleus in Wolbachia-induced cytoplasmic incompatibility in Drosophila melanogaster.

Genetics
P M Ferree, William Sullivan

Abstract

Cytoplasmic incompatibility (CI) is a reproductive sterility found in arthropods that is caused by the endoparasitic bacteria Wolbachia. In CI, host progeny fail to develop during early embryogenesis if Wolbachia-infected males fertilize uninfected females. It is widely accepted that this lethality is caused by some unknown Wolbachia-induced modification of the paternal nuclear material in the host testes. However, the direct means by which this modification leads to early embryonic death are currently unresolved. Results from previous studies suggested that CI lethality occurs as a result of asynchrony in cell cycle timing between the paternal and maternal pronuclei. This hypothesis can be tested experimentally by the prediction that the Wolbachia-modified paternal pronucleus should support androgenetic development (i.e., from the paternal pronucleus only). Using specific mutations in Drosophila melanogaster that produce androgenetic progeny, we demonstrate that the Wolbachia-induced modification inhibits this type of development. This result suggests that CI occurs independently of the maternal pronucleus and argues against pronuclear asynchrony as the primary cause of CI lethality. We propose that CI occurs instead as the re...Continue Reading

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·S L O'NeillH M Robertson
Jan 21, 1991·Journal of Theoretical Biology·L D Hurst
May 25, 1989·Nature·A W Murray, M W Kirschner
Oct 1, 1982·Genetics·J C Stone
Jan 15, 1981·Developmental Biology·C H von Beroldingen
Jun 1, 1995·The Journal of Cell Biology·G SluderF J Miller
Dec 5, 1995·Proceedings of the National Academy of Sciences of the United States of America·D J Komma, S A Endow
Jan 1, 1997·Current Topics in Developmental Biology·J LiuM F Wolfner
Nov 5, 1999·Annual Review of Microbiology·R StouthamerG D Hurst
Sep 6, 2000·Proceedings. Biological Sciences·J H Werren, D M Windsor
Feb 22, 2003·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Denis PoinsotHervé Merçot
Aug 5, 2003·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Harriet L Harris, Henk R Braig
Aug 28, 2003·Microbes and Infection·Uyen TramWilliam Sullivan
Jan 1, 1997·Annual Review of Entomology·J H Werren
Jul 1, 1986·Evolution; International Journal of Organic Evolution·Ary A HoffmannGail M Simmons

❮ Previous
Next ❯

Citations

Jul 13, 2013·Trends in Parasitology·Daniel LePage, Seth R Bordenstein
Aug 21, 2008·Annual Review of Genetics·Laura R SerbusWilliam Sullivan
Jun 2, 2011·PLoS Neglected Tropical Diseases·Kerstin FischerPeter U Fischer
Apr 24, 2008·Genetics·Sofia ZabalouKostas Bourtzis
Mar 25, 2014·Molecular Genetics and Genomics : MGG·Lori A McEachernVett K Lloyd
Jul 6, 2011·Research in Microbiology·George PapafotiouKostas Bourtzis
Mar 14, 2009·Comptes rendus biologies·Hervé Merçot, Denis Poinsot
Feb 11, 2015·PLoS Biology·Ewa Chrostek, Luis Teixeira
Apr 1, 2015·PLoS Pathogens·Laura R SerbusWilliam Sullivan
Sep 27, 2013·PLoS Pathogens·Peter KriesnerAndrew R Weeks
Aug 24, 2013·PLoS Neglected Tropical Diseases·Jan MedlockAlison P Galvani
May 20, 2006·PLoS Pathogens·Seth R BordensteinJennifer J Wernegreen
Jan 4, 2013·PLoS Genetics·Mark F RichardsonCasey M Bergman
Aug 21, 2013·PLoS Neglected Tropical Diseases·Yixin H YeElizabeth A McGraw
Sep 26, 2020·ELife·J Dylan ShropshireSeth R Bordenstein
Aug 20, 2019·Insect Biochemistry and Molecular Biology·Hai-Jian HuangXiao-Yue Hong

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.