A genome-based resource for molecular cardiovascular medicine: toward a compendium of cardiovascular genes

Circulation
D M HwangC C Liew

Abstract

Large-scale partial sequencing of cDNA libraries to generate expressed sequence tags (ESTs) is an effective means of discovering novel genes and characterizing transcription patterns in different tissues. To catalogue the identities and expression levels of genes in the cardiovascular system, we initiated large-scale sequencing and analysis of human cardiac cDNA libraries. Using automated DNA sequencing, we generated 43,285 ESTs from human heart cDNA libraries. An additional 41,619 ESTs were retrieved from public databases, for a total of 84,904 ESTs representing more than 26 million nucleotides of raw cDNA sequence data from 13 independent cardiovascular system-based cDNA libraries. Of these, 55% matched to known genes in the Genbank/EMBL/DDBJ databases, 33% matched only to other ESTs, and 12% did not match to any known sequences (designated cardiovascular system-based ESTs, or CVbESTs). ESTs that matched to known genes were classified according to function, allowing for detection of differences in general transcription patterns between various tissues and developmental stages of the cardiovascular system. In silico Northern analysis of known gene matches identified widely expressed cardiovascular genes as well as genes putati...Continue Reading

References

Feb 13, 1992·Nature·M D AdamsJ C Venter
Dec 1, 1990·European Heart Journal·R Fagard, J Conway
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Sep 1, 1989·Journal of Molecular and Cellular Cardiology·P S ColemanA M Samarel
Jan 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·S IzumoV Mahdavi
Dec 1, 1984·Pediatric Research·S UemuraJ M Jarmakani
Oct 20, 1995·Science·V E VelculescuK W Kinzler
Jan 1, 1995·Human Molecular Genetics·J M FrigerioJ L Iovanna
Jan 1, 1995·Journal of Molecular and Cellular Cardiology·L A KirshenbaumP K Singal
Apr 1, 1995·Nature Genetics·F S Collins
Apr 20, 1995·The New England Journal of Medicine·H WatkinsJ G Seidman
Jul 1, 1994·Nature Genetics·C FieldsJ C Venter
Oct 25, 1994·Proceedings of the National Academy of Sciences of the United States of America·C C LiewC Y Lee
Apr 1, 1993·Nature Genetics·A Ballabio
Jul 29, 1994·Biochemical and Biophysical Research Communications·K KonishiH Yasuno
Jan 1, 1994·Journal of Molecular and Cellular Cardiology·P M ButtrickJ Scheuer
Aug 1, 1993·Nature Genetics·M S BoguskiC M Tolstoshev
Mar 1, 1993·Nature Genetics·W Gish, D J States
May 3, 1996·Science·E N Olson, D Srivastava
May 3, 1996·Science·M T Keating, M C Sanguinetti
May 3, 1996·Science·J L Breslow
May 3, 1996·Science·G H Gibbons, V J Dzau
Jun 1, 1996·Journal of Molecular and Cellular Cardiology·Y W Fung, C C Liew
May 1, 1996·Current Opinion in Cardiology·K Schwartz, J J Mercadier
Jul 1, 1996·Journal of Molecular and Cellular Cardiology·J F CollinsR A Walsh
Oct 25, 1996·Science·G D SchulerT J Hudson
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·M SchenaR W Davis

❮ Previous
Next ❯

Citations

Feb 18, 1999·Journal of Cellular Biochemistry·M KotakaM M Waye
Mar 1, 2005·Journal of Molecular and Cellular Cardiology·Umesh C SharmaJos G Maessen
Feb 28, 2002·AIDS Treatment News
Sep 5, 2002·Atherosclerosis·Mikko O HiltunenSeppo Ylä-Herttuala
Jul 24, 1998·Trends in Genetics : TIG·E M Rubin, S Mockrin
Apr 23, 2003·Genomics·J David BarransChoong-Chin Liew
Sep 1, 2001·Trends in Cardiovascular Medicine·L W Stanton
Oct 24, 2001·Trends in Cardiovascular Medicine·N F Paoni, D G Lowe
Feb 25, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Teresa J BohlmeyerM Benjamin Perryman
Sep 26, 2003·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·Jun Yoshioka, Richard T Lee
Dec 18, 2001·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Ram Savan, Masahiro Sakai
May 23, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·D JägerU Müller-Werdan
Apr 24, 2012·Human Molecular Genetics·Felix W FriedrichLucie Carrier
Jan 11, 2013·Nucleic Acids Research·Xiangyue WuGary Brewer
Feb 19, 2000·Current Opinion in Lipidology·M O HiltunenS Ylä-Herttuala
Sep 26, 2000·Molecular and Cellular Biology·P H ChuJ Chen
Feb 16, 2002·Heart·Nigel J Brand, Paul J R Barton
May 17, 2003·Circulation Research·Raimond L Winslow, Mark S Boguski
Nov 19, 2008·Hypertension Research : Official Journal of the Japanese Society of Hypertension·Norihiro KatoSubrina Jesmin
May 19, 2005·Clinical Chemistry and Laboratory Medicine : CCLM·Choong Chin Liew
Jun 27, 2002·American Journal of Pharmacogenomics : Genomics-related Research in Drug Development and Clinical Practice·R Tolle
Aug 23, 2005·American Journal of Veterinary Research·Mark A Oyama, Sridar Chittur
Nov 28, 2002·European Journal of Heart Failure·Ondrej JuhaszKenneth R Boheler
Dec 12, 2001·European Journal of Heart Failure·F Mehraban, J E Tomlinson
Feb 13, 2001·Biochemical and Biophysical Research Communications·J D BarransC Liew
Jul 8, 1998·Proceedings of the National Academy of Sciences of the United States of America·M MaoZ Chen
Feb 24, 2001·Journal of Molecular and Cellular Cardiology·S BortoluzziG A Danieli
Oct 18, 2001·Journal of Molecular and Cellular Cardiology·A A DempseyC C Liew
Feb 22, 2001·Journal of Molecular and Cellular Cardiology·A A DempseyC C Liew
Mar 28, 2013·Cellular and Molecular Life Sciences : CMLS·Guido TaroneMara Brancaccio

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