A Genome Model to Explain Major Features of Neurodevelopmental Disorders in Newborns

Biomedical Informatics Insights
Bernard Friedenson

Abstract

The purpose of this study was to test the hypothesis that infections are linked to chromosomal anomalies that cause neurodevelopmental disorders. In children with disorders in the development of their nervous systems, chromosome anomalies known to cause these disorders were compared with foreign DNAs, including known teratogens. Genes essential for neurons, lymphatic drainage, immunity, circulation, angiogenesis, cell barriers, structure, epigenetic and chromatin modifications were all found close together in polyfunctional clusters that were deleted or rearranged in neurodevelopmental disorders. In some patients, epigenetic driver mutations also changed access to large chromosome segments. These changes account for immune, circulatory, and structural deficits that accompany neurologic deficits. Specific and repetitive human DNA encompassing large deletions matched infections and passed rigorous artifact tests. Deletions of up to millions of bases accompanied infection-matching sequences and caused massive changes in human homologies to foreign DNAs. In data from 3 independent studies of private, familial, and recurrent chromosomal rearrangements, massive changes in homologous microbiomes were found and may drive rearrangements...Continue Reading

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Citations

Oct 17, 2019·Lymphatic Research and Biology·Francine Blei

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Datasets Mentioned

BETA
U14567-U14574
AE004969
CP01323.1

Methods Mentioned

BETA
ubiquitination
acetylation
Histone acetylation

Software Mentioned

BLAT
StatsDirect
BLAST
Discontinuous Megablast

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