May 22, 2014

Multiple loci linked to inversions are associated with eye size variation in species of the Drosophila virilis phylad

BioRxiv : the Preprint Server for Biology
Henriette O'GeenNico Posnien

Abstract

The size and shape of organs is tightly controlled to achieve optimal function. Natural morphological variations often represent functional adaptations to an ever-changing environment. For instance, variation in head morphology is pervasive in insects and the underlying molecular basis is starting to be revealed in the Drosophila genus for species of the melanogaster group. However, it remains unclear whether similar diversifications are governed by similar or different molecular mechanisms over longer timescales. To address this issue, we used species of the virilis phylad because they have been diverging from D. melanogaster for at least 40 million years. Our comprehensive morphological survey revealed remarkable differences in eye size and head shape among these species with D. novamexicana having the smallest eyes and southern D. americana populations having the largest eyes. We show that the genetic architecture underlying eye size variation is complex with multiple associated genetic variants located on most chromosomes. Our genome wide association study (GWAS) strongly suggests that some of the putative causative variants are associated with the presence of inversions. Indeed, northern populations of D. americana share d...Continue Reading

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Mentioned in this Paper

Genome-Wide Association Study
Study
Genome
CRISPR-Cas Systems
Endonuclease
Endonuclease Activity
Murine
Cytokinesis of the Fertilized Ovum
Promoter
Maintenance of Crispr Repeat Elements

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