A genome-wide assessment of rare copy number variants in colorectal cancer

Oncotarget
Zhenli LiDandan Zhang

Abstract

Colorectal cancer (CRC) is a complex disease with an estimated heritability of approximately 35%. However, known CRC-related common single nucleotide polymorphisms (SNPs) can only explain ~0.65% of the heritability. This "missing heritability" may be explained partially by rare copy number variants (CNVs). In this study, we performed a genome-wide scan using Illumina Human-Omni Express BeadChip, 694 sporadic CRC cases and 1641 controls were eventually included in our analysis after quality control. The global burden analysis revealed a 1.53-fold excess of rare CNVs in CRC cases compared with controls (P < 1 × 10(-6)), and the difference being more pronounced for genic rare CNVs and CNVs overlapped with coding regions (1.65-fold and 1.84-fold, respectively, both P < 1 × 10(-6)). Interestingly, both the cases in the lowest and middle tertile of age carried a higher burden of rare CNVs comparing to the highest tertile. Furthermore, 639 CNV-disrupted genes exclusive to CRC cases were found to be significantly enriched in gene ontology (GO) terms concerning nucleosome assembly and olfactory receptor activity. Our study was the first to evaluate the burden of rare CNVs in sporadic CRC and suggested that rare CNVs contributed to the m...Continue Reading

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Citations

Nov 30, 2019·Gastroenterology Research and Practice·Jakub KarczmarskiJerzy Ostrowski
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Datasets Mentioned

BETA
GDS4382

Methods Mentioned

BETA
PCA
biopsy
nucleic acid extraction
genotyping

Software Mentioned

GenomeStudio
PennCNV
PLINK
Quantisnp
DAVID
Ensembl

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