A Genome-Wide Association Study for Host Resistance to Ostreid Herpesvirus in Pacific Oysters (Crassostrea gigas )

G3 : Genes - Genomes - Genetics
Alejandro P GutierrezRoss D Houston

Abstract

Ostreid herpesvirus (OsHV) can cause mass mortality events in Pacific oyster aquaculture. While various factors impact on the severity of outbreaks, it is clear that genetic resistance of the host is an important determinant of mortality levels. This raises the possibility of selective breeding strategies to improve the genetic resistance of farmed oyster stocks, thereby contributing to disease control. Traditional selective breeding can be augmented by use of genetic markers, either via marker-assisted or genomic selection. The aim of the current study was to investigate the genetic architecture of resistance to OsHV in Pacific oyster, to identify genomic regions containing putative resistance genes, and to inform the use of genomics to enhance efforts to breed for resistance. To achieve this, a population of ∼1,000 juvenile oysters were experimentally challenged with a virulent form of OsHV, with samples taken from mortalities and survivors for genotyping and qPCR measurement of viral load. The samples were genotyped using a recently-developed SNP array, and the genotype data were used to reconstruct the pedigree. Using these pedigree and genotype data, the first high density linkage map was constructed for Pacific oyster, co...Continue Reading

References

Sep 23, 2003·Marine Biotechnology·Masashi SekinoKenji Okoshi
Aug 11, 2005·Physical Review Letters·E B Brodie Of BrodieA Arneodo
Dec 5, 2006·Cellular Microbiology·Larissa KolesnikovaStephan Becker
Mar 27, 2007·Bioinformatics·Yurii S AulchenkoCornelia M van Duijn
Oct 10, 2007·American Journal of Human Genetics·Wei-Min Chen, Goncalo R Abecasis
Oct 24, 2008·Journal of Dairy Science·P M VanRaden
Sep 21, 2011·Marine Biotechnology·Xiang GuoLing F Kong
Apr 23, 2015·The Journal of General Virology·Ya-Chun YangLi-Kwan Chang
Jan 13, 2016·Scientific Reports·Jinzhuang DouZhenmin Bao
Jul 1, 2016·Genetics, Selection, Evolution : GSE·Hsin-Yuan TsaiRoss D Houston
Jan 1, 2016·Central-European Journal of Immunology·Beata Tokarz-DeptułaWiesław Deptuła
May 27, 2017·Science China. Life Sciences·Junwen ZhangBing-Ren Huang

❮ Previous
Next ❯

Citations

Mar 8, 2019·Viruses·Cas RetelPhiline G D Feulner
May 20, 2020·Frontiers in Immunology·Marco GerdolDelphine Destoumieux-Garzón
Sep 13, 2020·International Journal of Molecular Sciences·Maja A Zaczek-MoczydłowskaKatrina Campbell
Aug 29, 2018·G3 : Genes - Genomes - Genetics·Christos PalaiokostasRoss D Houston
Feb 2, 2021·Evolutionary Applications·S Elizabeth AlterEmmanuel Megafu
Mar 26, 2021·GigaScience·Carolina PeñalozaRoss D Houston

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

blastn
blastx
ParentCall2
EMMAX
Axiom Analysis Suite
Efficient Mixed - Model Association eXpedited ( EMMAX )
ASReml
GenABEL
Lep
FASTA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.