A genome-wide association study for milk production traits in Danish Jersey cattle using a 50K single nucleotide polymorphism chip

Journal of Animal Science
M D MaiB Guldbrandtsen

Abstract

Quantitative trait loci for milk production traits in Danish Jersey cattle were mapped by a genome-wide association analysis using a mixed model. The analysis incorporated 1,039 bulls and 33,090 SNP and resulted in 98 detected combinations of QTL and traits on 27 BTA. These QTL comprised 30 for milk index, 50 for fat index, and 18 for protein index. The evidence presents 33 genome-wide QTL on 14 BTA. Of these, 7 had effects on milk index, 21 on fat index, and 5 on protein index. Among the genome-wide QTL, 26 have been previously reported, 2 on BTA4 and BTA5 were new for milk index, and 5 on BTA4, BTA5, BTA13, BTA20, and BTA29 were new QTL for fat index. We found 7 pleiotropic or very closely linked QTL. Most of the QTL were associated with polymorphisms within narrow regions and several may represent the effects of polymorphisms of genes: DGAT1, casein, ARFGAP3, CYP11B1, and CDC-like kinase 4. By a chromosome-wide threshold, 65 additional QTL were detected. Many of them are likely to represent QTL. The results are interesting from a breeding perspective and contribute to the search for the genes causing the polymorphisms important for milk production traits.

References

Jan 7, 2003·Journal of Dairy Science·R J SpelmanR G Snell
Feb 26, 2004·Proceedings of the National Academy of Sciences of the United States of America·Bernard GrisartMichel Georges
Mar 17, 2009·Genetics, Selection, Evolution : GSE·Heidi NilsenSigbjørn Lien
Apr 25, 2009·PloS One·Lakshmi K MatukumalliCurtis P Van Tassell
May 19, 2009·Nature Reviews. Genetics·Michael E Goddard, Ben J Hayes
Aug 4, 2009·Journal of Animal Breeding and Genetics = Zeitschrift Für Tierzüchtung Und Züchtungsbiologie·D KolbehdariS S Moore

❮ Previous
Next ❯

Citations

May 17, 2011·BMC Genetics·Aniek C BouwmanJohan A M van Arendonk
Sep 11, 2012·Journal of Animal Science and Biotechnology·Hui ZhangHui Li
Sep 30, 2014·Reproduction in Domestic Animals = Zuchthygiene·D M HeringS Kaminski
Jun 20, 2015·Genetics, Selection, Evolution : GSE·Xiaoping WuGuosheng Su
Mar 13, 2014·Animal Reproduction Science·D M HeringS Kaminski
Mar 20, 2015·PloS One·Ngoc-Thuy HaHenner Simianer
Dec 27, 2016·Frontiers in Veterinary Science·Eduardo Casas, Marcus E Kehrli
Sep 15, 2017·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Mengistie TayeHeebal Kim
Feb 7, 2015·Asian-Australasian Journal of Animal Sciences·Kwang-Hyun ChoJoon-Ho Lee
May 10, 2019·Genome Génome / Conseil National De Recherches Canada·Periyasamy VijayakumarRamalingam Suresh
Jun 4, 2020·Journal of Animal Science and Biotechnology·Megan ScholtensHugh Blair
Jan 3, 2020·Animal Health Research Reviews·Shadi NayeriDan Tulpan
May 14, 2021·Translational Animal Science·Prakash B ThakorChaitanya G Joshi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.