A genome-wide association study identifies major loci affecting the immune response against infectious bronchitis virus in chicken

Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases
Chenglong LuoDingming Shu

Abstract

Coronaviruses are a hot research topic because they can cause severe diseases in humans and animals. Infectious bronchitis virus (IBV), belonging to gamma-coronaviruses, causes a highly infectious respiratory viral disease and can result in catastrophic economic losses to the poultry industry worldwide. Unfortunately, the genetic basis of the host immune responses against IBV is poorly understood. In the present study, the antibody levels against IBV post-immunization were measured by an enzyme-linked immunosorbent assay in the serum of 511 individuals from a commercial chicken (Gallus gallus) population. A genome-wide association study using 43,211 single nucleotide polymorphism markers was performed to identify the major loci affecting the immune response against IBV. This study detected 20 significant (P<1.16 × 10(-6)) effect single nucleotide polymorphisms for the antibody level against IBV. These single nucleotide polymorphisms were distributed on five chicken chromosomes (GGA), involving GGA1, GGA3, GGA5, GGA8, and GGA9. The genes in the 1-Mb windows surrounding each single nucleotide polymorphism with significant effect for the antibody level against IBV were associated with many biological processes or pathways related ...Continue Reading

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Citations

Sep 1, 2015·Current Opinion in Virology·Albrecht von BrunnJavier Carbajo-Lozoya
Sep 18, 2015·Ecology·Lloyd S PeckMelody S Clark
Aug 20, 2020·American Journal of Human Genetics·Marissa LoPrestiBenjamin D Solomon
Aug 7, 2021·Genes·Henriëtte van der Zwan, Rencia van der Sluis
Nov 3, 2021·Journal of Neurovirology·Atefeh BakhtazadMohammad Taghi Joghataei

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Methods Mentioned

BETA
chip
genotyping
enzyme-linked immunosorbent assay
ELISA
chips
PCA

Software Mentioned

Ensembl
Database for Annotation , Visualization and Integrated Discove...
TASSEL
DAVID
Ensembl Genome Browser
GAPIT
Haploview

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