A genome-wide association study of antidepressant response in Koreans

Translational Psychiatry
Woojae MyungD K Kim

Abstract

We conducted a three-stage genome-wide association study (GWAS) of response to antidepressant drugs in an ethnically homogeneous sample of Korean patients in untreated episodes of nonpsychotic unipolar depression, mostly of mature onset. Strict quality control was maintained in case selection, diagnosis, verification of adherence and outcome assessments. Analyzed cases completed 6 weeks of treatment with adequate plasma drug concentrations. The overall successful completion rate was 85.5%. Four candidate single-nucleotide polymorphisms (SNPs) on three chromosomes were identified by genome-wide search in the discovery sample of 481 patients who received one of four allowed selective serotonin reuptake inhibitor (SSRI) antidepressant drugs (Stage 1). In a focused replication study of 230 SSRI-treated patients, two of these four SNP candidates were confirmed (Stage 2). Analysis of the Stage 1 and Stage 2 samples combined (n = 711) revealed GWAS significance (P = 1.60 × 10(-8)) for these two SNP candidates, which were in perfect linkage disequilibrium. These two significant SNPs were confirmed also in a focused cross-replication study of 159 patients treated with the non-SSRI antidepressant drug mirtazapine (Stage 3). Analysis of t...Continue Reading

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Jun 17, 2016·Expert Opinion on Drug Metabolism & Toxicology·Chiara FabbriAlessandro Serretti
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Feb 6, 2017·Progress in Neuro-psychopharmacology & Biological Psychiatry·Judit García-GonzálezChiara Fabbri
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Jan 5, 2021·Pharmacogenetics and Genomics·Noam Morningstar-KywiScott A Mosley
Sep 12, 2021·Clinical Epigenetics·Marie CamerotaBarry M Lester

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Methods Mentioned

BETA
chip
genotyping
MDS

Software Mentioned

PASW Statistics
PLINK
SPSS

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