A Genome-Wide Association Study of Highly Heritable Agronomic Traits in Durum Wheat

Frontiers in Plant Science
Shubin WangGuangmin Xia

Abstract

Uncovering the genetic basis of key agronomic traits, and particularly of drought tolerance, addresses an important priority for durum wheat improvement. Here, a genome-wide association study (GWAS) in 493 durum wheat accessions representing a worldwide collection was employed to address the genetic basis of 17 agronomically important traits and a drought wilting score. Using a linear mixed model with 4 inferred subpopulations and a kinship matrix, we identified 90 marker-trait-associations (MTAs) defined by 78 markers. These markers could be merged into 44 genomic loci by linkage disequilibrium (r2 > 0.2). Based on sequence alignment of the markers to the reference genome of bread wheat, we identified 14 putative candidate genes involved in enzymes, hormone-response, and transcription factors. The GWAS in durum wheat and a previous quantitative trait locus (QTL) analysis in bread wheat identified a consensus QTL locus.4B.1 conferring drought tolerance, which was further scanned for the presence of potential candidate genes. A haplotype analysis of this region revealed that two minor haplotypes were associated with both drought tolerance and reduced plant stature, thought to be the effect of linkage with the semi-dwarfing gene ...Continue Reading

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Citations

Sep 30, 2020·International Journal of Molecular Sciences·Osvin ArriagadaAndrés R Schwember
Dec 2, 2020·Plants·Priyanka GuptaFilippo Maria Bassi
Sep 12, 2021·BMC Plant Biology·Matías SchierenbeckAndreas Börner
Jul 5, 2021·The Plant Journal : for Cell and Molecular Biology·Mian Abdur Rehman ArifAndreas Börner

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Methods Mentioned

BETA
genotyping

Software Mentioned

TCS
R
Structure
genetics
TASSEL
ImageJ
R package Lme4
Haploview

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