A Genome-wide Scan for Selective Sweeps in Racing Horses

Asian-Australasian Journal of Animal Sciences
Sunjin MoonHeebal Kim

Abstract

Using next-generation sequencing, we conducted a genome-wide scan of selective sweeps associated with selection toward genetic improvement in Thoroughbreds. We investigated potential phenotypic consequence of putative candidate loci by candidate gene association mapping for the finishing time in 240 Thoroughbred horses. We found a significant association with the trait for Ral GApase alpha 2 (RALGAP2) that regulates a variety of cellular processes of signal trafficking. Neighboring genes around RALGAP2 included insulinoma-associated 1 (INSM1), pallid (PLDN), and Ras and Rab interactor 2 (RIN2) genes have similar roles in signal trafficking, suggesting that a co-evolving gene cluster located on the chromosome 22 is under strong artificial selection in racehorses.

References

Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·M Nei, W H Li
Nov 14, 1997·Proceedings of the National Academy of Sciences of the United States of America·A C McPherron, S J Lee
Jun 10, 2000·Molecular and Cellular Biology·J SuzukiH Koide
Jul 20, 2002·Proceedings of the National Academy of Sciences of the United States of America·Thomas JansenKlaus Olek
Apr 30, 2003·Genesis : the Journal of Genetics and Development·Luc GrobetMichel Georges
Sep 4, 2003·Genome Research·Paul D ThomasApurva Narechania
Mar 23, 2004·Nature Genetics·Gabriella LindgrenHans Ellegren
Sep 22, 2007·Trends in Genetics : TIG·Se-Jin Lee
Oct 17, 2008·Molecular Biology and Evolution·Maria Anisimova, Carolin Kosiol
May 20, 2009·Bioinformatics·Heng Li, Richard Durbin
Jun 9, 2009·PloS One·Jingjing GuEmmeline W Hill
May 14, 2011·Molecular Ecology Resources·Laurent Excoffier, Heidi E L Lischer
Feb 6, 2013·PloS One·Jessica L PetersenMolly E McCue
Mar 4, 2014·PLoS Genetics·Saber QanbariHenner Simianer
Sep 3, 2014·Asian-Australasian Journal of Animal Sciences·Kyung-Do ParkHak-Kyo Lee

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Citations

Feb 24, 2018·Science·Charleen GaunitzLudovic Orlando
Jan 31, 2019·PloS One·Artur GurgulMonika Bugno-Poniewierska
Feb 20, 2019·Genome Génome / Conseil National De Recherches Canada·Hojjat Asadollahpour NanaeiAli Esmailizadeh
Dec 21, 2019·Reproduction in Domestic Animals = Zuchthygiene·Hojjat Asadollahpour NanaeiAli Esmailizadeh
May 15, 2020·Genome Génome / Conseil National De Recherches Canada·Siavash Salek ArdestaniYounes Miar
Sep 13, 2019·BMC Genetics·Katarzyna Ropka-MolikMonika Bugno-Poniewierska
Dec 18, 2018·Animal Science Journal = Nihon Chikusan Gakkaihō·Hironaga KakoiShun-Ichi Nagata
Jun 27, 2019·Acta Veterinaria Hungarica·Min-Ju Jeong, Byung-Hoon Jeong

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Datasets Mentioned

BETA
SRA053569

Methods Mentioned

BETA
electrophoresis

Software Mentioned

Picard
ASREML
Arlequin
BEAGLE
Burrows
Genome Analysis Toolkit
- Aligner ( BWA
SAMtools
PLINK

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