A genome-wide scan study identifies a single nucleotide substitution in MC1R gene associated with white coat colour in fallow deer (Dama dama).

BMC Genetics
Gerald ReinerHermann Willems

Abstract

The coat colour of fallow deer is highly variable and even white animals can regularly be observed in game farming and in the wild. Affected animals do not show complete albinism but rather some residual pigmentation resembling a very pale beige dilution of coat colour. The eyes and claws of the animals are pigmented. To facilitate the conservation and management of such animals, it would be helpful to know the responsible gene and causative variant. We collected 102 samples from 22 white animals and from 80 animals with wildtype coat colour. The samples came from 12 different wild flocks or game conservations located in different regions of Germany, at the border to Luxembourg and in Poland. The genomes of one white hind and her brown calf were sequenced. Based on a list of colour genes of the International Federation of Pigment Cell Societies ( http://www.ifpcs.org/albinism/ ), a variant in the MC1R gene (NM_174108.2:c.143 T > C) resulting in an amino acid exchange from leucine to proline at position 48 of the MC1R receptor protein (NP_776533.1:p.L48P) was identified as a likely cause of coat colour dilution. A gene test revealed that all animals of the white phenotype were of genotype CC whereas all pigmented animals were of...Continue Reading

References

Jan 15, 1974·Biochemistry·P Y Chou, G D Fasman
Sep 1, 1995·Mammalian Genome : Official Journal of the International Mammalian Genome Society·H KlunglandS Lien
Feb 15, 1996·European Journal of Biochemistry·A K ChakrabortyJ M Pawelek
Jun 1, 1996·Animal Genetics·R KühnF Pirchner
Feb 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·C CharlierM Georges
Dec 1, 1996·Mammalian Genome : Official Journal of the International Mammalian Genome Society·L MarklundL Andersson
Jun 29, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J J SeitzF C Buchanan
Jul 15, 1999·Biochemical and Biophysical Research Communications·H B SchiöthJ L Rees
Dec 22, 1999·Mammalian Genome : Official Journal of the International Mammalian Genome Society·J M NewtonG S Barsh
May 19, 2000·Annals of the New York Academy of Sciences·Z Abdel-MalekC Akcali
Aug 22, 2000·Pigment Cell Research·M Tachibana
Sep 22, 2001·Current Biology : CB·K RitlandH D Marshall
May 20, 2003·Pigment Cell Research·Tsuneto KushimotoVincent J Hearing
Jan 17, 2004·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Sheila M SchmutzMerete Fredholm
Aug 31, 2007·BMC Structural Biology·Sofia Khan, Mauno Vihinen
Apr 28, 2009·Genome Biology·Aleksey V ZiminSteven L Salzberg
Jun 10, 2009·Bioinformatics·Heng LiUNKNOWN 1000 Genome Project Data Processing Subgroup
Sep 10, 2009·The Journal of Biological Chemistry·Ana B Pérez-OlivaJosé C García-Borrón
Sep 12, 2009·Genes & Genetic Systems·Tomofumi ShimadaHitoshi Suzuki
Jul 3, 2010·Science China. Life Sciences·YongWang MiaoYaPing Zhang
Dec 17, 2010·British Poultry Science·X L GuoH Q Zheng
Sep 29, 2011·Pigment Cell & Melanoma Research·Iraz T AydinFriedrich Beermann
Apr 25, 2012·Animal Genetics·Sheila M Schmutz, Dayna L Dreger
Sep 13, 2013·Genes & Genetic Systems·Hitoshi Suzuki
Jan 28, 2014·Genetics, Selection, Evolution : GSE·Lauren L Hulsman HannaClare A Gill
Apr 8, 2014·Animal Genetics·Yi ZhangYachun Wang
Feb 17, 2015·TheScientificWorldJournal·Bathrachalam ChandramohanAntonietta La Terza
Jun 9, 2016·Genome Biology·William McLarenFiona Cunningham
Jan 3, 2018·Molecular Genetics and Genomics : MGG·Nóra Á BanaLászló Orosz
Jun 13, 2018·The Journal of Heredity·Faisal AlmathenOlivier Hanotte

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Methods Mentioned

BETA
amino
PCR
electrophoresis

Software Mentioned

PICARDtools
Ensemble
FastQC
SAMtools
bcl2fastq Conversion
Illumina
Ensembl
BWA

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