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A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells

EMBO Reports

Jul 30, 2019

Sacha BenaoudiaThomas Henry

Abstract

Caspase-4, the cytosolic LPS sensor, and gasdermin D, its downstream effector, constitute the non-canonical inflammasome, which drives inflammatory responses during Gram-negative bacterial infections. It remains unclear whether other proteins regulate cytosolic LPS sensing, particularly...read more

Mentioned in this Paper

Genome-Wide Association Study
Study
Interferon Regulatory Factors
Genes
CASP4 protein, human
IRF1 protein, human
Human Cell Line
Gram-Negative Bacteria
Induced Pluripotent Stem Cells
Interferons
4
21
Paper Details
References
  • References63
  • Citations3
12345...
  • References63
  • Citations3
1

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GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity

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A genome-wide screen identifies IRF2 as a key regulator of caspase-4 in human cells

EMBO Reports

Jul 30, 2019

Sacha BenaoudiaThomas Henry

PMID: 31353801

DOI: 10.15252/embr.201948235

Abstract

Caspase-4, the cytosolic LPS sensor, and gasdermin D, its downstream effector, constitute the non-canonical inflammasome, which drives inflammatory responses during Gram-negative bacterial infections. It remains unclear whether other proteins regulate cytosolic LPS sensing, particularly...read more

Mentioned in this Paper

Genome-Wide Association Study
Study
Interferon Regulatory Factors
Genes
CASP4 protein, human
IRF1 protein, human
Human Cell Line
Gram-Negative Bacteria
Induced Pluripotent Stem Cells
Interferons
4
21

Similar Papers Found In These Feeds

Inflammasome and Pyroptosis

Pyroptosis is a form of necrotic and inflammatory programmed cell death induced by inflammatory caspases, one of which is activated by Inflammasome, a multiprotein oligomer responsible for the activation of inflammatory responses. Discover the latest research on inflammasome and pyroptosis here.

PSCs in Development and Disease

Pluripotent stem cells (PSCs) are progenitor cells that can give rise to three basic layers of the body, thus potentially allowing the production of any cells or tissues needed by the body for repair. Here is the latest research on the PSCs in development and disease.

Related Papers

Journal of Molecular Cell Biology

GSDMB promotes non-canonical pyroptosis by enhancing caspase-4 activity

Journal of Molecular Cell BiologyOctober 16, 2018
Qin ChenXiang Gao
Paper Details
References
  • References63
  • Citations3
12345...
  • References63
  • Citations3
1
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