A genome-wide study of gene activity reveals developmental signaling pathways in the preimplantation mouse embryo

Developmental Cell
Q Tian WangMagdalena Zernicka-Goetz

Abstract

The preimplantation development of the mammalian embryo encompasses a series of critical events: the transition from oocyte to embryo, the first cell divisions, the establishment of cellular contacts, the first lineage differentiation-all the first subtle steps toward a future body plan. Here, we use microarrays to explore gene activity during preimplantation development. We reveal robust and dynamic patterns of stage-specific gene activity that fall into two major phases, one up to the 2-cell stage (oocyte-to-embryo transition) and one after the 4-cell stage (cellular differentiation). The mouse oocyte and early embryo express components of multiple signaling pathways including those downstream of Wnt, BMP, and Notch, indicating that conserved regulators of cell fate and pattern formation are likely to function at the earliest embryonic stages. Overall, these data provide a detailed temporal profile of gene expression that reveals the richness of signaling processes in early mammalian development.

References

Feb 1, 1996·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Y SaijohH Hamada
Aug 4, 1999·Nature Genetics·P LiuA Bradley
Mar 14, 2000·Current Opinion in Immunology·G Sherlock
Feb 24, 2001·Nature·K Piotrowska, M Zernicka-Goetz
Feb 27, 2001·Nucleic Acids Research·L R BaughC P Hunter
Jun 1, 2001·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·P P TamR R Behringer
Jul 13, 2001·Current Opinion in Genetics & Development·C C LuE J Robertson
Aug 7, 2001·Frontiers in Bioscience : a Journal and Virtual Library·T P FlemingI Fesenko
Mar 14, 2002·Genesis : the Journal of Genetics and Development·Berenika PlusaMagdalena Zernicka-Goetz
Mar 20, 2002·Molecular and Cellular Endocrinology·R G Gosden
Sep 28, 2002·Science·Michelle N ArbeitmanKevin P White
Oct 3, 2002·Nature Cell Biology·Berenika PlusaMagdalena Zernicka-Goetz
Jan 7, 2003·Genes & Development·Ariel A AvilionRobin Lovell-Badge
Aug 29, 2003·Development·Toshihiko FujimoriYo-Ichi Nabeshima

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Citations

Sep 12, 2006·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Jesse MagerMarisa S Bartolomei
Apr 6, 2006·Cell and Tissue Research·Guo Qing TongSoon Chye Ng
Apr 21, 2007·Chromosome Research : an International Journal on the Molecular, Supramolecular and Evolutionary Aspects of Chromosome Biology·Valeria MericoSilvia Garagna
Jul 13, 2007·Stem Cell Reviews·M William LenschThorsten M Schlaeger
Jan 8, 2013·Molecular Aspects of Medicine·Shuang ZhangD Randall Armant
Jan 29, 2013·Molecular Aspects of Medicine·Lei LiJurrien Dean
Apr 9, 2013·Molecular Aspects of Medicine·Anna Ajduk, Magdalena Zernicka-Goetz
Aug 30, 2008·Nature·Franz-Josef MüllerJeanne F Loring
Mar 6, 2010·Nature Protocols·Fuchou TangM Azim Surani
Jun 6, 2012·Nature Structural & Molecular Biology·Laure WeillRaúl Méndez
Aug 26, 2006·Reproduction, Fertility, and Development·Xing-Yu LiNam-Hyung Kim
Mar 29, 2007·Reproduction, Fertility, and Development·Xiang-Shun Cui, Nam-Hyung Kim
Jan 21, 2009·Reproduction, Fertility, and Development·Sadie L MarjaniX Cindy Tian
Dec 10, 2008·Proceedings of the National Academy of Sciences of the United States of America·W A KuesH Niemann
Oct 21, 2009·Proceedings of the National Academy of Sciences of the United States of America·Jiang FuWei Hsu
Feb 18, 2010·Proceedings of the National Academy of Sciences of the United States of America·Ertugrul M OzbudakOlivier Pourquié
Mar 24, 2010·Proceedings of the National Academy of Sciences of the United States of America·Samantha A MorrisMagdalena Zernicka-Goetz
Mar 5, 2008·Cloning and Stem Cells·Norshariza NordinJohn O Mason
May 23, 2012·Stem Cells and Development·Jason T K Hwang, Gregory M Kelly
Aug 15, 2008·Molecular Biology of the Cell·Karin Lykke-AndersenMagdalena Zernicka-Goetz
May 8, 2013·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Sandy S C HungMinoru S H Ko
Mar 31, 2006·Human Reproduction·Said AssouSamir Hamamah
May 15, 2008·Human Reproduction·Gayle M JonesAlan O Trounson
Sep 8, 2011·Human Reproduction Update·B C J M FauserC M Howles
Dec 2, 2008·Molecular Human Reproduction·Christine E BellAndrew J Watson
Feb 19, 2009·Molecular Human Reproduction·Qi ChenEnkui Duan
May 6, 2011·Biology of Reproduction·Hua Pan, Richard M Schultz
Mar 24, 2012·Biology of Reproduction·Aaron J Hsueh, Rami Rauch
Sep 10, 2013·Genes & Development·Elisa Rodríguez-SeguelFrancesca M Spagnoli
Aug 25, 2005·Cold Spring Harbor Symposia on Quantitative Biology·D SolterB B Knowles
Nov 22, 2008·Cold Spring Harbor Symposia on Quantitative Biology·W N de VriesD Solter
Aug 24, 2007·Clinical and Experimental Pharmacology & Physiology·Keith T Jones

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