A genome-wide study of recombination rate variation in Bartonella henselae.

BMC Evolutionary Biology
Lionel GuySiv G E Andersson

Abstract

Rates of recombination vary by three orders of magnitude in bacteria but the reasons for this variation is unclear. We performed a genome-wide study of recombination rate variation among genes in the intracellular bacterium Bartonella henselae, which has among the lowest estimated ratio of recombination relative to mutation in prokaryotes. The 1.9 Mb genomes of B. henselae strains IC11, UGA10 and Houston-1 genomes showed only minor gene content variation. Nucleotide sequence divergence levels were less than 1% and the relative rate of recombination to mutation was estimated to 1.1 for the genome overall. Four to eight segments per genome presented significantly enhanced divergences, the most pronounced of which were the virB and trw gene clusters for type IV secretion systems that play essential roles in the infection process. Consistently, multiple recombination events were identified inside these gene clusters. High recombination frequencies were also observed for a gene putatively involved in iron metabolism. A phylogenetic study of this gene in 80 strains of Bartonella quintana, B. henselae and B. grahamii indicated different population structures for each species and revealed horizontal gene transfers across Bartonella spe...Continue Reading

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Citations

Sep 12, 2014·PLoS Genetics·Philipp EngelNancy A Moran
Apr 22, 2018·Applied and Environmental Microbiology·Mustafa O JibrinErica M Goss
Jun 25, 2019·Cellular Microbiology·Maxime Québatte, Christoph Dehio
Jan 24, 2019·MBio·Pedro González-TorresToni Gabaldón

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Datasets Mentioned

BETA
SRP002470
UGA10

Methods Mentioned

BETA
454 sequencing
gene exchange
whole-genome shotgun sequencing
PCR

Software Mentioned

Glimmer3
blastp
Mauve
blastn
TOPCONS
genoPlotR
CONSEL
IV
yn00
MAFFT

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