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A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes

The Journal of Allergy and Clinical Immunology

Jun 18, 2014

Sunita SharmaBenjamin A Raby

Abstract

Genome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes by enabling prioritization of putative functional variants for association te...read more

Mentioned in this Paper

Real-Time Polymerase Chain Reaction
Genome-Wide Association Study
Pathogenic Aspects
Biochemical Pathway
Quantitative Trait Loci
Desaturase
ORMDL3 gene
Nucleosomes
T-Lymphocyte
FADS2 gene
4
60
Paper Details
References
  • References25
  • Citations23
123
  • References25
  • Citations23
123

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Related Papers

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Lung eQTLs to help reveal the molecular underpinnings of asthma

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A genome-wide survey of CD4(+) lymphocyte regulatory genetic variants identifies novel asthma genes

The Journal of Allergy and Clinical Immunology

Jun 18, 2014

Sunita SharmaBenjamin A Raby

PMID: 24934276

DOI: 10.1016/j.jaci.2014.04.011

Abstract

Genome-wide association studies have yet to identify the majority of genetic variants involved in asthma. We hypothesized that expression quantitative trait locus (eQTL) mapping can identify novel asthma genes by enabling prioritization of putative functional variants for association te...read more

Mentioned in this Paper

Real-Time Polymerase Chain Reaction
Genome-Wide Association Study
Pathogenic Aspects
Biochemical Pathway
Quantitative Trait Loci
Desaturase
ORMDL3 gene
Nucleosomes
T-Lymphocyte
FADS2 gene
4
60

Feeds With Similar Papers

Aminoglycosides

Aminoglycoside is a medicinal and bacteriologic category of traditional Gram-negative antibacterial medications that inhibit protein synthesis and contain as a portion of the molecule an amino-modified glycoside. Discover the latest research on aminoglycoside here.

Mast Cells in Allergy

Mast cells are key components involved in allergic reactions. They release chemical mediators that are responsible for the clinical symptoms of an allergic reaction. These chemical mediators include histamine, cytokines, leukotrienes and many others. Discover the latest research on mast cells in allergy here.

Related Papers

PLoS Genetics

Lung eQTLs to help reveal the molecular underpinnings of asthma

PLoS GeneticsDecember 5, 2012
Ke HaoDon D Sin
The Journal of Allergy and Clinical Immunology

Genome-wide association study of the age of onset of childhood asthma

The Journal of Allergy and Clinical ImmunologyMay 9, 2012
Erick FornoJuan C Celedón
Paper Details
References
  • References25
  • Citations23
123
  • References25
  • Citations23
123

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