A genome-wide transcriptional study reveals that iron deficiency inhibits the yeast TORC1 pathway

Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms
Antonia María RomeroSergi Puig

Abstract

Iron is an essential micronutrient that participates as a cofactor in a broad range of metabolic processes including mitochondrial respiration, DNA replication, protein translation and lipid biosynthesis. Adaptation to iron deficiency requires the global reorganization of cellular metabolism directed to optimize iron utilization. The budding yeast Saccharomyces cerevisiae has been widely used to characterize the responses of eukaryotic microorganisms to iron depletion. In this report, we used a genomic approach to investigate the contribution of transcription rates to the modulation of mRNA levels during adaptation of yeast cells to iron starvation. We reveal that a decrease in the activity of all RNA polymerases contributes to the down-regulation of many mRNAs, tRNAs and rRNAs. Opposite to the general expression pattern, many genes including components of the iron deficiency response, the mitochondrial retrograde pathway and the general stress response display a remarkable increase in both transcription rates and mRNA levels upon iron limitation, whereas genes encoding ribosomal proteins or implicated in ribosome biogenesis exhibit a pronounced fall. This expression profile is consistent with an activation of the environmental...Continue Reading

Citations

Jul 19, 2020·Genes·Tania Jordá, Sergi Puig
Oct 6, 2020·Frontiers in Microbiology·Lucía Ramos-AlonsoSergi Puig
Dec 12, 2020·Computational and Structural Biotechnology Journal·Raquel Sorribes-DaudenSergi Puig
Jan 29, 2021·The Biochemical Journal·Sandra Montella-ManuelMaria Angeles de la Torre-Ruiz
Jun 3, 2021·Microorganisms·Antonia María RomeroSergi Puig
Jul 15, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·María Teresa Martínez-Pastor, Sergi Puig

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