A genomic- and proteomic-based hypothesis on the eclectic effects of systemic interleukin-2 administration in the context of melanoma-specific immunization

Cells, Tissues, Organs
Monica C PanelliFrancesco M Marincola

Abstract

Among human cancers, melanoma is characterized by an almost unique predisposition to regress in response to immune therapy. Recent clinical studies suggest that the frequency of this favorable event is enhanced by combining T-cell-directed active specific immunization with the systemic administration of interleukin (IL)-2. While waiting for additional clinical experience to confirm this observation, we embraced the working hypothesis that this combination provides superior response rates than either treatment alone. In particular, we have focused our interest on the paradoxical observation that active specific immunization consistently induces circulating CD8+ T cells capable of recognizing in ex vivo assays tumor cells, but cannot induce tumor regression alone. In these settings, it appears that combining the systemic administration of IL-2 is almost an absolute requirement for the induction of clinical responses. Here, we will expand on previous speculations on the postulated mechanism(s) of action of systemic IL-2 administration and, based on original data recently derived through high-throughput transcriptional and post-translational analysis, we will suggest an explanation for the eclectic effects of IL-2 administration in...Continue Reading

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Citations

Jan 25, 2005·Springer Seminars in Immunopathology·Ena WangFrancesco M Marincola
Aug 5, 2004·Current Oncology Reports·Monica C PanelliFrancesco M Marincola
Mar 6, 2004·Seminars in Cancer Biology·Vladia MonsurròFrancesco M Marincola
Oct 7, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Geoffrey R WeissEna Wang
Jun 30, 2006·Journal of Translational Medicine·Ping JinFrancesco M Marincola
Aug 18, 2006·Journal of Translational Medicine·Ruggero RidolfiAngela Riccobon
Feb 9, 2006·Journal of Translational Medicine·L GabrieleF M Belardelli
Jun 19, 2009·Journal of Translational Medicine·Hideaki TaharaFrancesco M Marincola
Jun 4, 2010·Expert Review of Vaccines·Davide BedognettiFrancesco M Marincola
Feb 26, 2008·Expert Opinion on Biological Therapy·Ena WangFrancesco M Marincola
May 25, 2004·Expert Opinion on Biological Therapy·Monica C PanelliFrancesco M Marincola
Jun 4, 2004·Journal of Translational Medicine·Monica C PanelliFrancesco M Marincola
Nov 20, 2003·Journal of Translational Medicine·Ping Jin, Ena Wang
Dec 4, 2004·PLoS Medicine·Tor B StugePeter P Lee
Oct 17, 2013·British Journal of Cancer·D BedognettiF M Marincola
Aug 19, 2006·Immunological Investigations·Ena WangFrancesco M Marincola
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Oct 8, 2020·Journal for Immunotherapy of Cancer·Ena WangFrancesco Marincola
May 18, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Monica C PanelliFrancesco M Marincola

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