A genomic comparison of faster-sex, faster-X, and faster-male evolution between Drosophila melanogaster and Drosophila pseudoobscura.

Journal of Molecular Evolution
Heidi MustersRama S Singh

Abstract

A genomic comparison of Drosophila melanogaster and Drosophila pseudoobscura provides a unique opportunity to investigate factors involved in sequence divergence. The chromosomal arrangements of these species include an autosomal segment in D. melanogaster which is homologous to part of the X chromosome in D. pseudoobscura. Using orthologues to calculate rates of nonsynonymous (d(N)) substitutions, we found genes on the X chromosome to be significantly more diverged than those on the autosomes, but it is not true for segment 3L-XR which is autosomal in D. melanogaster (3L) and X-linked in D. pseudoobscura (XR). We also found that the median d(N) values for genes having reproductive functions in either the male, the female, or both sexes are higher than those for sequences without reproductive function and even higher for sequences involved in male-specific function. These estimates of divergence for male sex-related sequences are most likely underestimates, as the very rapidly evolving reproductive genes would tend to lose homology sooner and thus not be included in the comparison of orthologues. We also noticed a high proportion of male reproductive genes among the othologous genes with the highest rates of d(N). Reproductive ...Continue Reading

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Citations

Jul 16, 2010·Development Genes and Evolution·Csaba AdámViktor Dombrádi
Jun 25, 2013·Trends in Genetics : TIG·Richard P Meisel, Tim Connallon
Apr 10, 2007·Genome Research·Judith E MankHans Ellegren
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Mar 3, 2020·Genome Biology and Evolution·Kai HayesKai Zeng
Aug 23, 2018·Genetics·Ana LlopartJosep M Comeron

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