A genomic view of lymphocyte development

Current Opinion in Immunology
Reinhard Hoffmann, Fritz Melchers

Abstract

RNA expression profiles of consecutive stages of mouse and human B-cell precursors, and of mouse T-cell precursors, from DJ re-arranged states to mature lymphocytes have been generated using high-density oligonucleotide arrays. Approximately 10% of all genes present on the arrays are differentially expressed across all cellular stages of each of the lineages. Approximately half of these are differentially expressed during both T-cell and B-cell differentiation. Many of the genes that are shared are involved in cell cycle regulation and DNA replication, whereas most of the signaling and adhesion molecules and transcription factors are expressed in a lineage-specific manner. Comparable stages of the T-and B-lineage developmental programs share only a few genes. By contrast, homologous genes differentially expressed during both human and mouse B-cell development have very similar expression patterns.

References

Apr 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J EberwineP Coleman
Mar 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R N Van GelderJ H Eberwine
Oct 1, 1996·Proceedings of the National Academy of Sciences of the United States of America·M SchenaR W Davis
Jan 7, 1998·Nature Biotechnology·L WodickaD J Lockhart
Dec 1, 1996·Nature Biotechnology·D J LockhartE L Brown
Oct 24, 1998·Immunology Today·P GhiaF Melchers
Dec 9, 1998·Proceedings of the National Academy of Sciences of the United States of America·M B EisenD Botstein
Mar 17, 1999·Proceedings of the National Academy of Sciences of the United States of America·P TamayoT R Golub
Sep 25, 2001·Immunity·A L ShafferL M Staudt
Jan 10, 2002·Genome Research·Reinhard HoffmannFritz Melchers
Apr 6, 2002·Bioinformatics·Winston Patrick KuoIsaac S Kohane
May 4, 2002·Science·Philipp KapranovThomas R Gingeras
May 10, 2002·Nucleic Acids Research·Tony YuenStuart C Sealfon
Jun 28, 2002·Cell·Fernando MaciánAnjana Rao
Nov 19, 2002·Nature Immunology·Alexandra FlemmingHassan Jumaa
Sep 2, 2005·Nature·UNKNOWN Chimpanzee Sequencing and Analysis Consortium

❮ Previous
Next ❯

Citations

Oct 11, 2007·BMC Immunology·Ivan G CostaAlexander Schliep
Nov 10, 2013·PloS One·Johanna SalonenMauno Vihinen
Aug 12, 2008·British Journal of Haematology·Pieter Van VlierbergheJules P P Meijerink
Aug 23, 2006·Expert Opinion on Drug Metabolism & Toxicology·Russell Huby, Jonathan D Tugwood
Feb 3, 2005·European Journal of Immunology·Kazuo OhnishiTakeyuki Shimizu
Aug 23, 2005·European Journal of Immunology·Vladimir V TemchuraCharlotte Esser
Feb 13, 2004·The Journal of Biological Chemistry·Robert MånssonMikael Sigvardsson
Oct 21, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Menno C van ZelmJacques J M van Dongen
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sabine Middendorp, Rudolf W Hendriks

❮ Previous
Next ❯

Related Concepts

Related Feeds

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.