PMID: 2118149Aug 1, 1990Paper

A genotoxicological study of the new local anaesthetic carbamate derivatives carbisocaine, heptacaine and pentacaine

Journal of Applied Toxicology : JAT
P Siekel

Abstract

The potential mutagenic activity of three carbamate derivatives with local anaesthetic activity was investigated. Genotoxic activity was observed after application of Carbisocaine on Euglena gracilis, whereas no activity was detected by Carbisocaine, Heptacaine and Pentacaine on Salmonella typhimurium, Escherichia coli and Drosophila melanogaster.

References

Feb 1, 1976·Mutation Research·M H Green, W J Muriel
Nov 1, 1976·Mutation Research·A KappasW J Muriel
Oct 1, 1975·Bulletin of Environmental Contamination and Toxicology·M UchiyamaK Yoshikawa
Jan 1, 1976·Mutation Research·Y ShirasuT Kada
Jul 1, 1977·Mutation Research·R D BlevinsJ D Regan
Dec 1, 1975·Proceedings of the National Academy of Sciences of the United States of America·J McCannB N Ames
Jan 1, 1985·Teratogenesis, Carcinogenesis, and Mutagenesis·M MacorP Siekel
Jan 1, 1988·European Journal of Drug Metabolism and Pharmacokinetics·S BezekZ Kállay
Mar 1, 1986·Biopharmaceutics & Drug Disposition·S BezekL Benes

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Citations

Dec 31, 2002·Mutation Research·Alisson Marques de Miranda Cabral GontijoDaisy Maria Favero Salvadori
Jul 23, 2015·BioMed Research International·Mariana G Braz, Bensu Karahalil
Sep 9, 2006·Current Opinion in Anaesthesiology·Vladimir VeghKlaus Hahnenkamp

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