PMID: 8583569Mar 1, 1996Paper

A genotype study of the c-Ha-ras-1 locus in human bladder tumors

The Journal of Urology
H BittardG R Adessi

Abstract

To clarify the role of the c-Ha-ras-1 gene in bladder cancer predisposition and prognosis. The c-Ha-ras-1 locus was studied by Southern blotting in white blood cells and tumor samples obtained from 126 patients with bladder cancer (74 Ta-T1 and 52 T2-T4). A comparison with 84 unaffected patients and a survival analysis were performed. The patients with bladder cancer presented 7 different c-Ha-ras-1 alleles, 12 different genotypes, heterozygosity in 49% of cases and a loss of heterozygosity (in the tumor) in 13 cases. The most frequent allele (a1, 6.6 kb) was present in 83% of patients. Heterozygosity correlated with vascular invasion in the tumor (p < 0.0001). In the small subgroup of 11 patients with rare alleles and genotypes, these alleles and genotypes occurred more often in patients with T2-T4 tumors (p < 0.01 for alleles and genotypes), aneuploid tumors (p < 0.001, p < 0.005) and tumors with vascular invasion (p < 0.01, p < 0.005). However, in this study, the majority of patients with high risk tumors possessed common alleles and genotypes. Survival analysis showed that neither the c-Ha-ras-1 genotype nor allelomorphism was an independent prognostic factor. Elsewhere, no rare allele occurred more frequently in bladder ca...Continue Reading

References

Jan 1, 1991·Molecular Carcinogenesis·A WestonH Sugimura
Oct 15, 1987·International Journal of Cancer. Journal International Du Cancer·J IshikawaT Sugiyama
Jun 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·J FujitaS A Aaronson
May 1, 1985·The Journal of Experimental Medicine·M V ViolaJ Schlom
Oct 1, 1985·Molecular and Cellular Biology·S PulcianiM Barbacid
Jun 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·C J DerG M Cooper

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Citations

Jul 13, 2002·International Journal of Cancer. Journal International Du Cancer·Carla H van GilsJack A Taylor
Jul 12, 2003·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·M L QuekJ P Stein

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